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Metabolism and neural differentiation in childhood neuroblastoma
(2017-05-19)
Neuroblastoma is the most common and aggressive extracranial solid tumor during childhood. MYCN-amplification is found in approximately 25 % of all neuroblastoma cases, and is defined as high-risk disease. Development of ...
Postmenopausal hormone therapy and cardiovascular risk
(2018-01-09)
Introduction and aims: Postmenopausal hormone therapy (HT) is the most effective treatment for menopausal symptoms, but its safety has been debated during the past 15 years. Previous observational studies showed benefits ...
Monoclonal gammopathy of undetermined significance : natural course and comorbidities
(2016-12-21)
Monoclonal gammopathy of undetermined significance (MGUS) is a plasma cell disorder characterized by an overproduction of monoclonal immunoglobulins. MGUS is asymptomatic but clinically relevant since annually 0.5-1.5% of ...
Epidemiological studies of medication use and effectiveness in bipolar disorder
(2017-09-19)
In the last decades, new treatments for bipolar disorder (BD) have emerged, prompting a decrease in the use of lithium – the former “gold standard” for relapse prevention, and increasing the possibilities for individualized ...
Clinical and epidemiological studies on prognostic and predicitve factors in cutaneous melanoma
(2013-09-25)
Background: Cutaneous malignant melanoma (CMM) is one of the most rapidly increasing cancers in Sweden, as in many other western countries. In clinical practice, the histopathological evaluation has remained the basis for ...
Single implants in the anterior maxilla in young adults
(2023-05-22)
Background: Single anterior implants are frequently used in the treatment of patients with single anterior tooth loss. Compared with other types of implant treatments, single implants are commonly performed in younger ...
Preoperative radiotherapy in rectal cancer : aspects on fractionation and timing of surgery
(2019-04-30)
Neo-adjuvant radiotherapy (RT) in rectal cancer (RC) reduces the risk for local recurrence (LR). The optimal fractionation or time to surgery is not determined. The focus areas of this thesis are different RT-courses and ...