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Mitochondria and cellular energy metabolism in platinum chemotherapy
(2009-09-18)
Chemotherapy is a major strategy in the treatment of cancer. Unfortunately, treatment of advanced cancers often fails due to tumor resistance to chemotherapeutic drugs. Studies of cell death signaling induced by chemotherapeutic ...
Socio-economic differences in the healthcare utilisation of older persons in Sweden
(2021-09-22)
The global population is ageing and this demographic change has important implications for the provision of healthcare and social care. Older people often have multiple and complex health problems and a range of different ...
Long-term clinical, histological and virological outcomes after sustained virologic response in patients with chronic hepatitis C
(2017-05-09)
Successful antiviral treatment of chronic hepatitis C (HCV), resulting in Sustained Virologic Response (SVR) has been shown to reduce the risk for liver related complications, hepatocellular carcinoma (HCC) and death. ...
Strategies of gene and immune therapy for tumors and viral diseases
(2003-04-04)
In the treatment of tumors and viral diseases such as HIV-1 infection, immunotherapeutic strategies do not seem to have enough capacity to eradicate an already established disease. However, these strategies could play a ...
Fetal and neonatal risk factors for diseases caused by disturbances in the function of the immune system
(2009-10-30)
Diseases caused by disturbances in the function of the immune system are a heterogeneous group of disorders, including e g allergic and autoimmune diseases. Several of these diseases have become increasingly common during ...
HMBG1 and other soluble factors in HIV-1 pathogenesis
(2009-01-30)
The innate immune system is the first defense mechanism invading
pathogens encounter. Macrophages, dendritic cells and
cytokines/chemokines are important factors for the functionality of the
innate immunity, and provide ...
A study of the transition from premalignancy to clinical prostate cancer
(2005-09-16)
Prostate cancer remains the most commonly diagnosed life-threatening malignancy and the second leading cause of death from cancer in men. However, little is known about molecular mechanisms that underline its initiation ...
Diagnostic tests for adiposity and metabolic risk factors in adolescence : results from the Stockholm weight development study (SWEDES)
(2005-03-25)
Background: Despite growing concern about the development of pediatric
obesity, there is still controversy about its classification.
International classification systems have been proposed and national
systems are in ...
Elucidation of pro-apoptotic signaling induced by cisplatin
(2003-02-07)
A major clinical problem regarding treatment of malignant tumors with anticancer drugs is inherent or acquired resistance to therapy. One factor contributing to drug resistance of cancer cells is failure to undergo apoptosis. ...
Risk factors for criminal offending among men with schizophrenia
(2006-02-15)
Background: There is consistent evidence for an association between schizophrenia and criminal offending. With better knowledge of the relation between schizophrenia and criminal offending, better and more cost-effective ...