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Mitochondria and cellular energy metabolism in platinum chemotherapy
(2009-09-18)
Chemotherapy is a major strategy in the treatment of cancer. Unfortunately, treatment of advanced cancers often fails due to tumor resistance to chemotherapeutic drugs. Studies of cell death signaling induced by chemotherapeutic ...
Toxicity of metal and metal oxide nanoparticles : the importance of physicochemical properties and cellular uptake
(2012-10-04)
The use of nanoparticles holds great promises in many technical as well as medical applications. However, development of new technologies, such as nanotechnology, is connected with uncertainties and risks. The same properties ...
Understanding chronic immunodeficiency disorders through assessment of cytotoxic lymphocyte function
(2017-09-20)
Representing an evolving and diverse group of syndromes, immunodeficiencies can currently be viewed as a spectrum of disorders where a dysfunction of the immune system plays a significant etiologic role. Cytotoxic lymphocytes ...
Studies of the device perfect capsule in an animal model to reduce lens epithelial cell proliferation
(2008-09-12)
The sealed-capsule irrigation device, the Perfect Capsule, is a surgical
device designed to target lens epithelial cells (LECs) during cataract
surgery and prevent posterior capsule opacification (PCO). This is
especially ...
LXR and aromatase knock-out mice : animal models providing insight into human diseases
(2009-01-01)
In our characterization of mouse strains carrying mutations in nuclear
receptor and aromatase genes we have found phenotypes which resemble four
human diseases: benign prostatic hyperplasia (BPH), Sjögren s syndrome
(SS), ...
Multimethodological brain imaging studies of human epilepsy
(2007-08-10)
Although the pathophysiological mechanisms of human epilepsy are
extensively investigated, many questions remain unanswered. One is
whether idiopathic generalized epilepsies (IGE) have anatomical
substrates. Another is ...
Glucocorticoid receptor cross-talk with NF-kappaB and AP-1 : functional role and mechanisms
(2005-03-18)
The protein investigated in this thesis is the glucocorticoid receptor (GR), which is a ligand activated transcription factor that belongs to the superfamily of nuclear hormone receptors. The GR contains three functional ...
Immunogenicity of and apoptosis modulation by Epstein-Barr virus (EBV)-encoded latent membrane protein-1 (LMP1) : implications for nasopharyngeal carcinoma
(2005-05-19)
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus which infects more than 90% of individuals in the population, and has been shown to be associated with a variety of human tumors. The viral genome encodes a number ...
Autonomic cardiac control in patients with epilepsy : spectral analysis of heart rate variability
(2006-11-03)
The heart is affected by the central nervous system via sympathetic and para-sympathetic efferents from autonomic centres in the brain stem. By assessing the beat to beat variation of the RR-intervals of the heart, i.e. ...
Optimization of suicide gene therapy in stem cell transplantation with special reference to the selection marker OuaSelect
(2009-04-22)
For many patients suffering from leukemia and other hematological malignancies, allogeneic hematopoietic stem cell transplantation (HSCT) represents the only curative approach. However, an optimal HSCT procedure is yet to ...