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A study of the transition from premalignancy to clinical prostate cancer
(2005-09-16)
Prostate cancer remains the most commonly diagnosed life-threatening malignancy and the second leading cause of death from cancer in men. However, little is known about molecular mechanisms that underline its initiation ...
Programming of cardiovascular and metabolic functions by thyroid hormone signaling
(2014-09-26)
Thyroid Hormones (TH) regulate myriad processes, such as development, metabolism and cardiovascular functions, by controlling gene expression through binding to nuclear thyroid hormone receptors, TRα and TRβ. While patients ...
Studies of b-AP15 : a novel inhibitor of proteasome deubiquitinase activity
(2017-04-07)
Bortezomib was the first FDA approved proteasome inhibitor that was initially very successful in treatment of multiple myeloma patients but acquired resistance and adverse side-effect highly decreased patients’ quality of ...
Molecular monitoring of acute graft-versus-host disease after allogenic stem cell transplantation
(2004-08-20)
Acute graft-versus-host disease (GVHD) remains a major barrier to the wider application of allogeneic stem cell transplantation (SCT) for a variety of diseases. GVHD occurs when the transplanted donor Tlymphocytes react ...
Characterization of malignant pleural mesothelioma : possibilities for an individualized therapeutic arsenal
(2014-01-28)
Less than 50% of malignant mesothelioma patients respond to standard chemotherapy treatment and there is a great need to identify these patients, and find their best treatment options. The aim of this thesis was to increase ...
The HPA axis in type 2 diabetes : some aspects in relation to insulin sensitivity, beta-cell function and IGF-I/IGFBP-1
(2014-02-21)
Type 2 diabetes (T2D) is characterized by insulin resistance and β-cell failure, abdominal obesity, hypertension and dyslipidemia. These symptoms are also characteristic of states of hypercortisolism. The purpose of this ...