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Dihydroorotate dehydrogenase : new insights into an old target
(2020-01-24)
Purine and pyrimidine nucleotides are important for both biosynthetic and regulatory pathways in cells. As constituents of the DNA and RNA molecules, the requirements for nucleotides in actively dividing cells are increased. ...
Molecular characterization of Mycobacterium tuberculosis complex isolates from Sweden
(2010-04-21)
Tuberculosis (TB), caused by the Mycobacterium tuberculosis complex
(MTC), is a serious infection in man and animals. According to the World
Health Organisation (WHO), about one third of the world´s population is
infected ...
Psoriasis : studies of phenotype at onset and of associated cardiovascular morbidity
(2005-08-12)
Psoriasis is a complex inflammatory skin disorder, affecting 2-3% of the population in the western world. The etiology of psoriasis is not yet known. However it is likely that its pathogenesis involves interplay between ...
Comorbidity in risk and outcome of hematological malignancies
(2016-03-01)
Hematological malignancies are a group of neoplasms that originate from the bone marrow or lymphatic tissues representing close to 10% of the overall cancer burden in the world. Clinical course, prognosis and survival ...
Nutrition, energy metabolism and body composition in the frail elderly
(2006-12-20)
During aging a reduction of energy metabolism, energy intake and fat free
mass can be seen. Some elderly patients experience more pronounced body
weight loss that may lead to malnutrition states. The reasons for the
unintentional ...
Quantitative echocardiographic methods for patients with acute coronary syndrome
(2014-07-09)
Background: The aim of this thesis was to evaluate two diagnostic and two prognostic quantitative echocardiographic methods for patients with acute coronary syndrome (ACS).
Methods:
Velocity tracking (VeT) presents ...
Molecular genetic studies of psoriasis susceptibility in 6p21.3
(2005-02-18)
Psoriasis is a common and chronic skin disease with multifactorial background. It affects approximately 2% of the Swedish population and is characterized by inflammatory and scaly lesions. The aetiology of psoriasis is not ...
Bioactive peptides and proteins in disease
(2004-05-17)
Regulatory peptides and marker proteins are important to study in order to understand disease mechanisms. This applies of course also to our common diseases where all relationships are not yet known. Cancer and diabetes ...
On the detection and management of urinary bladder carcinoma
(2008-11-07)
Aims: To describe the diagnosis and clinical course of an unselected population-based cohort of patients with newly diagnosed transitional cell carcinoma of the urinary bladder. To assess if random bladder biopsies and the ...
Studies on the inflammatory response in experimental acute pyelonephritis and its importance for the development of renal scarring
(2002-01-08)
Acute pyelonephritis especially in childhood is a serious and globally common bacterial infection. The infecting microorganism is often derived from the patient's own bowel flora and mainly affects the renal parenchyma and ...