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Transcriptional mechanisms directing terminal differentiation of B lineage cells
(2002-11-01)
The interaction between the B cell receptor (surface immunoglobulin) and
its ligand (antigen) can result in extensive cell growth and induction of
differentiation. The terminally differentiated B cell fulfills the
ultimate ...
On the role of complement activation following traumatic brain injury
(2004-04-27)
Traumatic brain injury (TBI) is one of the leading causes of early death and disability among young people in the industrial world. The final clinical outcome in terms of morbidity/mortality is not only related to the ...
Studies on the role of NGF in arthritis-induced pain transmission using gait and weight bearing as outcome measures
(2019-10-11)
Pain is one of the most common reasons for seeking healthcare, with approximately forty percent of those suffering from chronic pain having joint pain. Osteoarthritis is the most common cause of joint pain, but currently ...
Studies on syndecan-1 in mesenchymal tumors
(2010-01-08)
The syndecans are a four-member family of type I transmembrane proteoglycans. Their core proteins have a short cytoplasmic domain, a transmembrane domain and a large N-terminal extracellular domain possessing glycosaminoglycan ...
Children with low anorectal malformations and their parents : quality of life, physical and psychosocial function
(2018-10-31)
Anorectal malformations (ARM) are congenital anomalies affecting 1 in 3 000 births. The malformation varies from very minor to complex and can be divided in to low, intermediate, and high form of ARM. Children with a low ...
Molecular genetic studies on cerebrospinal fluid monoamine metabolites in psychotic patients and healthy individuals
(2015-02-26)
Dopamine, serotonin and noradrenaline are the major monoamines in the human central nervous system (CNS) and following their basic pathways they are degraded to their major metabolites homovanillic acid (HVA), 5-hydroxyi ...
Factors influencing the metabolism of inorganic arsenic in humans
(2007-05-11)
Inorganic arsenic (iAs), a naturally occurring drinking water contaminant, is a potent human carcinogen and toxicant. It is believed that in humans, as well as in most mammals, inorganic arsenic is biotransformed via ...
Antibiotic resistance and antibiotic consumption with focus on Escherichia coli and Pseudomonas aeruginosa
(2007-05-04)
Aims: The general aims of the present studies were to assess the levels of antibiotic resistance, in relation to antibiotic consumption at the Karolinska University Hospital, Solna (KS) and at 11 other Swedish hospitals, ...
Glossopharyngeal breathing
(2008-03-21)
Introduction and aims: The technique of glossopharyngeal breathing was introduced already in the 1950 s, but today, few health professionals are aware of its uses. The technique is performed by using the glossopharyngeal ...
The many faces of p57Kip2 : acting in apoptosis, differentiation and cytoskeleton reorganisation
(2009-08-28)
p57Kip2 is a known cyclin dependent kinase inhibitor, which has been suggested to be a tumor suppressor gene. Indeed various human cancers show a reduction in p57Kip2 expression, indicating that this protein might be of ...