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Human iPSC derived neural cells as models of brain development and as tools in pharmaceutical drug discovery
(2018-12-12)
Human brain evolution has resulted in a cognitive superiority compared to all other animals. Unique cortical structures and expanding progenitor populations have been associated with the possibility for developing a highly ...
Urocortins in the zebrafish brain and redox regulation of embryonic development through glutaredoxins
(2012-03-29)
The cellular redox state is a central regulator of embryonic development. Redox homeostasis and thiol redox signaling are modulated through glutaredoxins (Grxs), glutathione dependent thiol-disulfide oxidoreductases. Grxs ...
Regulation of the vertebrate transcriptome in development and disease
(2016-01-15)
In the last decade we have seen a tremendous development in the omics area (genomics,
transcriptomics, proteomics etc.), making high throughput methods increasingly costeffective and available. The development in ...
Regulation of human thioredoxin and glutaredoxin systems by oxidation and S-nitrosylation
(2008-03-21)
The homeostasis of intracellular redox status has a crucial role in the
cell survival and different processes such as DNA synthesis, gene
expression, enzymatic activity, etc. This homeostasis is achieved via an
intense ...
Elucidation of thioredoxin reductase 1 as an anticancer drug target
(2015-08-20)
Cancer constantly finds ways to survive, so we must find new ways to stop it. A major attribute of cancer cells is increased oxidative stress, occurring in the form of reactive oxygen species (ROS). Basal ROS generation ...
From cholesterol to oxidative stress in Alzheimer's disease : a wide perspective on a multifactorial disease
(2008-11-14)
Epidemiological studies have provided evidence that high cholesterol
levels in midlife and lack of antioxidants could render people more
susceptible to develop AD. The aim of this thesis project was to get a
more profound ...
Studies of the thioredoxin system in redox signaling and oxidative stress
(2020-05-08)
Reactive oxygen species exert reversible posttranslational modifications in proteins containing redox sensitive thiols, thereby affecting several cellular processes and protein functions. Reductive enzyme systems, such as ...
Characterization of thioredoxin related protein of 14 kDa and its role in redox signaling
(2016-02-22)
Reversible reduction/oxidation (redox) reactions play key roles in cellular signaling pathways.
Particularly cysteine residues in proteins can be modified by reactive oxygen-, nitrogen- or sulfur
species (ROS, RNS, RSS), ...
Biochemical properties of human glutaredoxins
(2004-05-07)
Glutaredoxins (Grxs) are highly conserved thiol-disulfide oxidoreductases that utilize electrons from the tripeptide glutathione (GSH) to catalyze thiol-disulfide exchange reactions. Bacteria, yeast and plants contain ...
Shame and stigma in weight management during pregnancy and post bariatric surgery : perspectives of patients and healthcare providers
(2020-04-20)
Background: Body mass index (BMI) increases across the world, yet there is an alarming lack of obesity prevention and treatments that are effective, harmless and available for everyone in need. Stigmatizing attitudes towards ...