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Regulation of the vertebrate transcriptome in development and disease
(2016-01-15)
In the last decade we have seen a tremendous development in the omics area (genomics,
transcriptomics, proteomics etc.), making high throughput methods increasingly costeffective and available. The development in ...
Experimental combination therapy of brain cancer cell models
(2012-11-21)
Epigenetic alterations and aberrant expression of genes controlling epigenetic mechanisms have been identified in several cancers, including medulloblastoma and glioma, the most common primary brain tumors in children and ...
Novel immunological mechanisms and factors in systemic lupus erythematosus-related cardiovascular disease
(2006-03-31)
Systemic Lupus Erythematosus (SLE) is a clinical syndrome of autoimmune origin. It manifests in diverse clinical and serological patterns and is considered to represent a prototype multisystemic autoimmune disease. The ...
Mammalian sperm flagella and cilia
(2009-04-17)
In mammals, both sperm flagella and cilia are axoneme-containing organelles. The sperm flagella are major parts of the spermatozoa that are male gametes produced in the testis from progenitor spermatogonia through a process ...
Studies of histone modification systems in Schizosaccharomyces pombe
(2010-05-26)
The genetic information in every cell is carried in the DNA. In eukaryotes the DNA is wrapped twice around proteins called histones forming a repeating unit called the nucleosome, in fibers known as chromatin. Nucleosomes ...
The role of substance P in respiratory control in the newborn : effects of morphine and nicotine
(2008-11-07)
We breathe in order to maintain oxygen, carbon dioxide and pH levels
within the physiological range in response to the metabolic demands of
the body. To achieve this, the respiratory control system is dependent on
input ...
Role of posttranslational modifications in regulation of Notch and transcriptional coactivator mastermind-like 1
(2011-12-29)
The Notch signaling is an evolutionary conserved pathway enabling short range cell-cell interactions, crucial for diverse developmental and physiological processes during embryonic and adult life. The Mastermind-like (MAML) ...
Platelet angiogenic activities : a concert of multiple players
(2016-11-15)
Angiogenesis, the sprouting of new capillaries from pre-existing blood vessels, is crucial for many physiological and pathological processes. Platelets are an important player in angiogenesis, whilst understanding of ...
Aspects of chemotherapy and photon and proton radiotherapy in patients with gastric cancer
(2015-02-13)
Gastric cancer remains a major health problem worldwide. The addition of chemotherapy
alone or in combination with radiotherapy to surgery in local gastric cancer improves
outcome. In more advanced stages, the optimal ...
Platelet angiogenic activities and their regulation on endothelial progenitor cell functions
(2015-08-12)
Platelets are essential for haemostasis and thrombosis, but also play a major role in angiogenesis. Activated platelets recruit progenitor cells and induce differentiation into endothelial progenitor cells (EPCs), which ...