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Clinical aspects on treatment of deep venous thrombosis with a low molecular weight heparin
(1998-04-29)
Dalteparin is a low molecular weight heparin (LMWH) with a mean mw of 4-6000 D. Compared to unfractionated heparin (UFH), a higher bioavailability, a longer half-life and a more predictable dose-response is achieved after subcutaneous injections...
Studies of targeted therapy in breast cancer using trastuzumab : HER2 testing and trastuzumab treatment, clinical and economic evaluation
(2011-09-22)
The incidence in breast cancer has more than tripled in Sweden since the 1960-ies. During the same time period the 5-year survival rate has increase from around 65% to almost 90%. The survival increase is mainly related ...
Chronic kidney disease of unknown etiology in Central America and Sri Lanka : renal morphology and clinical characteristics
(2017-09-07)
Background: Chronic kidney disease (CKD) is a global health problem. The most common etiologies of CKD are diabetes mellitus, hypertension, and glomerulonephritis, but over the last several decades a high prevalence of CKD ...
Health-related quality of life of different patient groups in Swedish national quality registers : longitudinal studies of EQ-5D data and application of different value sets
(2021-03-02)
Background: EQ-5D data on patients’ health-related quality of life (HRQoL) are collected in roughly 40% of about 100 National Quality Registers (NQRs) in Sweden. The aim of the thesis was to increase knowledge on the use ...
Neuroblastoma incidence, biology and outcome : with special emphasis on quantitative analysis of tyrosine hydroxylase mRNA in blood and bone marrow
(2009-05-14)
Neuroblastoma, the most common malignant disease of early childhood,
accounts for 6% of childhood malignancies but is responsible for 9% of
paediatric cancer related deaths. The tumour originates from cells in the
neural ...
Human salmonellosis : impact of travel and trade from a Swedish perspective
(2006-09-08)
Background: Salmonellosis is one of the most important gastrointestinal infections in humans. The vast majority of Swedish Salmonella cases have acquired the disease abroad, reflecting both a large number of Swedish ...
Hepatitis C in chronic kidney disease and kidney transplantation : with special reference to epidemiology and treatment
(2003-10-31)
Hepatitis C (HCV) is a clinical problem in infected kidney transplant patients but is also a cause of renal disease and vasculitis. Standard therapy for HCV is a combination of interferon and ribavirin. Renal patients have ...
Mifepristone for preoperative treatment of uterine leiomyoma
(2011-04-29)
AIM: To explore the clinical impact and its molecular regulation on uterine leiomyomas in preoperative treatment with mifepristone, a progesterone receptor modulator (PRM).
BACKGROUND: Uterine leiomyomas are highly ...
Electrical impedance of human skin and tissue alterations : mathematical modeling and measurements
(2012-12-17)
The overall aim of the studies in this thesis is twofold. One is oriented towards calibrating a classifier in differentiating between malignant melanoma and benign nevi of the skin. The other concerns the development of a ...
Interactions between neuronal nicotinic acetylcholine receptors, N-methyl-aspartate receptors and beta-amyloid in the brain of genetically modified mice : implications for Alheimer's disease
(2005-11-25)
The amyloid hypothesis is one of the leading theories in the search for the cause of Alzheimer's disease (AD) and is based on the theory that hyperproduction and accumulation of amyloid betapeptide (Abeta) in the brain ...