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Structural enzymology of the biosynthesis of polyketide antibiotics
(2004-05-14)
Anthracyclines are an important group of aromatic antibiotics that exhibit antitumour activity, which makes them useful in treatment of various cancers. They are synthesised in the polyketide biosynthetic pathway as secondary ...
Neuroblastoma incidence, biology and outcome : with special emphasis on quantitative analysis of tyrosine hydroxylase mRNA in blood and bone marrow
(2009-05-14)
Neuroblastoma, the most common malignant disease of early childhood,
accounts for 6% of childhood malignancies but is responsible for 9% of
paediatric cancer related deaths. The tumour originates from cells in the
neural ...
Studies on the mechanisms of sorafenib-induced cell death
(2014-08-22)
In 2008, 26% of all deaths were cancer-related, making this group of diseases the second leading cause of death in the EU countries. Derailment of tyrosine kinase signaling is one important pre-requisite towards tumorigenesis. ...
Mechanistic insights into the biosynthesis of polyketide antibiotics
(2006-11-24)
Anthracyclines are a group of aromatic polyketide compounds with significant medical importance due to their antineoplastic properties. Doxorubicin and daunorubicin members of this family are among the two most commonly ...
Enzymatic activation of oxygen in the biosynthesis of polyketide antibiotics
(2009-09-04)
The electron structure of molecular oxygen (O2) is such that it cannot spontaneously react with organic molecules, a feature that protects organisms from oxidative stress. However, oxygenases can insert O2 in organic ...
DNA topoisomerases and nucleosome dynamics in fission yeast
(2015-05-12)
The organization of DNA and associated proteins into chromatin allows for compaction and protection of large eukaryotic genomes. However, it also poses a challenge to fundamental cellular processes such as DNA replication, ...