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Studies of targeted therapy in breast cancer using trastuzumab : HER2 testing and trastuzumab treatment, clinical and economic evaluation
(2011-09-22)
The incidence in breast cancer has more than tripled in Sweden since the 1960-ies. During the same time period the 5-year survival rate has increase from around 65% to almost 90%. The survival increase is mainly related ...
Ah receptor mediated toxicity : studies in vitro and in a transgenic mouse model
(2007-02-01)
The polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls are ubiquitously present in the environment. Humans are exposed mainly through diet to continuous low levels which on average are in close proximity to ...
Corticosteroids in advanced cancer : epidemiology, symptom relief and patient experiences
(2007-04-06)
Cortisol is the principal circulating glucocorticoid in man and has a
wide variety of effects in the body. In advanced metastatic cancer,
glucocorticoids are used to alleviate symptoms such as anorexia, poor
strength ...
Functional study of nuclear receptors and bile acids in the modulation of cholesterol homeostasis
(2013-10-08)
Cholesterol carries multiple biological functions in the body, and imbalanced cholesterol metabolism leads to atherosclerosis and cardiovascular diseases. The present thesis aims to extend the knowledge of cholesterol ...
Regulation of striated muscle contraction
(2008-08-28)
Background and Aims: Muscle contraction involves cross-bridge interaction between actin and myosin filaments, which is regulated by variations of intracellular [Ca2+] and influenced by several external control systems. To ...
Neuromotor development and brain structure in children born extremely preterm
(2022-11-22)
Children born extremely preterm (EPT) are increasingly surviving but it is well known that they face a high risk of brain injury and neurodevelopmental impairments. The overall aim of the studies included in this thesis ...
WRAP53β and scaRNA2 on their journey to repair the DNA
(2018-03-22)
WRAP53β is a multifunctional protein involved in several cellular processes like Cajal body formation, telomere maintenance and DNA repair. WRAP53β is responsible for targeting factors to specific cellular locations, and ...
Host-microbe interactions in coxsackievirus infection : focus on innate immunity
(2010-05-28)
Coxsackievirus group B (CVB) is a common virus that usually causes only
mild symptoms in humans. However, occasionally these infections result in
severe diseases like meningitis, myocarditis and pancreatitis. In
addition, ...
Functional characterization of the alternative reading frame protein p14ARF
(2004-05-06)
A deeper understanding of the molecular events underlying tumor development is a prerequisite for the design of novel and efficient therapies. Inactivation of the p53 and retinoblastoma (Rb) tumor suppressor pathways appears ...
Role of c-di-GMP signalling in bacterial-host interactions
(2010-09-09)
Bacteria have various ways to sense environmental signals and to adapt their behavior and physiology through different signaling systems. Secondary messenger signaling, amplified by enzymatic activity, rapidly transmits a ...