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Internet-delivered cognitive behavior therapy for adolescents with irritable bowel syndrome : a randomized controlled trial
(2017-06-30)
OBJECTIVES: Few treatments have been able to effectively manage pediatric irritable bowel syndrome (IBS). Internet-delivered cognitive behavior therapy (Internet-CBT) based on exposure for abdominal symptoms is effective ...
The non-human primate as a model of human parkinsonism
(2006-01-06)
The motor deficits seen in Parkinson’s disease (PD) are the result of a loss of catecholaminergic neurons from the substantia nigra (SN) and the associated loss of striatal dopamine. Clinical signs become evident once ...
Neurorestorative strategies involving neurogenesis, neuronal precursors and stem cells in animal models of Parkinson's disease
(2009-10-08)
The general aims of the thesis is to provide evidence for neurogenesis in the adult substantia nigra pars compacta (SNpc), where the dopamine-producing neurons lost in Parkinson's disease (PD) reside; to optimize methods ...
The role of X-ray imaging and musculoskeletal ultrasound in the diagnosis and management of rheumatoid arthritis
(2014-10-31)
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease characterized by symmetric joint inflammation that often involves the small joints of the hands and feet, with progressive destruction, deformity, and ...
Urinary thymine dimer as a biomarker of exposure to ultraviolet radiation
(2013-03-27)
Exposure to ultraviolet radiation (UVR) is associated with all three major forms of skin cancer; squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and cutaneous malignant melanoma (CMM). Different exposure patterns ...
Tartrate resistant acid phosphatase 5a : a potential regulator of adipocyte cell number and differentiation in white adipose tissue
(2015-04-02)
Tartrate-resistant acid phosphatase (TRAP) exists in two isoforms, TRAP 5a which is monomeric and TRAP 5b which is a dimer generated by proteolytic cleavage of TRAP 5a, that exhibit different functions and localizations. ...
HLA genetics in multiple sclerosis
(2012-04-20)
Multiple sclerosis (MS) is a chronic disease in which both genetic and environmental risk factors contribute to disease susceptibility. MS patients suffer from inflammatory lesions in the central nervous system which results ...
Astrocytes in glioblastoma : enhancers of tumor growth, predictors of patient survival and potential therapeutic targets
(2020-02-18)
The tumor microenvironment plays an important role in glioblastoma, the most malignant primary brain tumor in adults. Astrocytes are a major component of the glioblastoma tumor microenvironment; therefore, their influence ...
HCMV-induced epigenetic alterations : a novel pathway to CNS tumors?
(2018-06-01)
Aberrant DNA hypermethylation at CpG islands is a well-established phenomenon involved in transcriptional silencing of tumor suppressor genes. CpG island hypomethylation-mediated reactivation of oncogenes is also documented ...
A percentile approach to time-to-event outcomes
(2015-11-18)
Evaluating survival percentiles is a possible approach for the analysis of time-to-event outcomes that
moves the focus from risk to time, as the proportion of events is xed and the time by which that
proportion is ...