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Genetic regulation of autoimmunity in experimental neuroinflammation
(2016-05-27)
Multiple sclerosis (MS) is a chronic inflammatory disease that affects the central nervous system
causing axonal demyelination and leads to significant disabilities. MS affects mainly young adults and
incidence of disease ...
Ageing and inflammation with focus on end-stage renal diseases : genetic and epigenetic factors
(2016-05-27)
The presence of ageing-associated disorders at a relatively young age in patients suffering from chronic kidney disease (CKD) has led to the hypothesis that CKD is characterized by accelerated ageing, resulting in a marked ...
The role of transcriptional repression in Shh signalling and patterning of the ventral neural tube
(2004-05-07)
From flies to humans, members of the Hedgehog (Hh) family of secreted signalling molecules play a vital role in determining cell fate and patterning during embryonic development. In vertebrates, Sonic Hedgehog (Shh) act ...
Role of transcription factors in sensory neuron specification
(2007-02-09)
The interface between our mind and the internal and external environments is the peripheral nervous system. A range of different sensory neuron subtypes detects cold, heat, pain, touch, and other stimuli. Specialized ...
Pulmonary tuberculosis and Pneumocystis jiroveci pneumonia in HIV-infected patients in Ethiopia
(2007-02-12)
The objective of this study initially was to determine the prevalence of
culture-verified pulmonary tuberculosis in TB suspects and investigate
the impact of human immunodeficiency virus (HIV) infection on the
prevalence, ...
Wnt/beta-catenin signaling in midbrain dopaminergic neurons
(2006-04-07)
Parkinson's disease (PD) is caused by a progressive degeneration of the dopaminergic (DA) neurons of the substantia nigra. However, the mechanisms underlying the degeneration remain elusive and there is no cure for P1) at ...
Surviving cystectomy due to urinary bladder cancer with maintained quality of life
(2010-10-15)
In 2008 1694 men and 626 women in Sweden were diagnosed as having bladder cancer. The character of bladder cancer is highly variable ranging from moderately serious development of superficial tumors to much more serious ...
ADHD, epilepsy, and related childhood psychopathology : understanding shared genetic risk, developmental trajectories, and pharmacological treatment safety
(2018-03-29)
Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder, affecting 5-7% of children and 2.5-5% of adults worldwide. The disorder is characterized by excessive and age-inappropriate symptoms ...
Control of HIV and other sexually transmitted infections : studies in Tanzania and Zambia
(2007-03-13)
Background: Efforts to control STI/HIV in sub-Saharan Africa has met with
difficulties. Although the epidemic seems to be levelling off, prevalence
and incidence are still high in many parts. In spite of 20 years of ...