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Diabetes mellitus type two in Stockholm County, Sweden : examining ethnicity as an independent risk factor—a cross-sectional study
(2015-06-24)
Background: Diabetes mellitus type two (T2DM) is a major global health issue. It is caused by an interaction between genetic and environmental factors. It is a metabolic disorder characterised by elevated blood glucose ...
Dynamics of drug-resistant minor viral populations and phenotypic drug susceptibility in diverse HIV-1 subtypes
(2019-05-06)
Antiretroviral therapy (ART) has significantly reduced mortality in human immunodeficiency virus type 1 (HIV-1) infection, both in high- and low/middle-income countries (LMIC). However, the development of drug resistance ...
Towards a cohesive understanding of the DNA damage response as a therapeutic target
(2022-06-01)
At the basis of the complexity that forms a human being is a highly regulated interplay of factors found at a molecular, cellular, and macroscopic level. Ever since we evolved to work this way, even the slightest dysregulation ...
Translational genomics of HIV-1 subtype C in India : molecular phylogeny and drug resistance
(2013-05-16)
This thesis describes the translational genomics of HIV-1subtype C in India from its origin to therapeutic response with the aim to improve our knowledge for better therapeutic and preventive strategies to combat HIV/AIDS. ...
Non-coding RNA-based therapeutics and biomarkers for treatment and detection of vascular disease
(2021-12-23)
Cardiovascular disease (CVD), with atherosclerosis as its main underlying pathology, is the most prominent cause of death worldwide. Progression and rupture of atherosclerotic plaques lead to potential adverse pathological ...