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Studies in safety promotion for preschool children
(2000-08-11)
The multifactorial aetiology in childhood injuries indicates a need for a systemic approach in the development of safety promotion strategies. In the present thesis, the feasibility of a systemic approach for the development ...
National surveys : a way to manage treatment strategies in Parkinson's disease? Pharmaceutical prescribing patterns and patient experiences of symptom control and their impact on disease
(2013-07-17)
BACKGROUND: The purpose of this study was to draw conclusions from patient-reported experiences in two national surveys from Scandinavia with the intention of comparing treatment strategies and increasing our knowledge of ...
Post-polio syndrome : physiotherapeutic analysis and interventions
(2013-01-24)
This thesis presents four studies focusing on outcomes of gait performance using gait analysis and/or the Six-minute-walk test (6MWT), in patients with post-polio syndrome (PPS). Further, resistance training in combination ...
Redox alterations in inflammatory diseases : diabetes, kidney failure and cancer
(2018-08-10)
In order to combat oxidative stress and maintain the intracellular redox homeostasis, cells are equipped with antioxidant systems. The thioredoxin and glutaredoxin systems are the major thiol reducing systems and central ...
Oral mucositis and periodontal disease in patients with primary or acquired immunodeficiencies
(2013-09-11)
The infection and inflammation in the oral cavity are commonly related to the skewed interaction between host immunity and inhabiting microorganisms. Both primary and acquired immunodeficiency conditions are frequently ...
Studies on pericytes in health and disease
(2010-05-21)
Pericytes are the perivascular mural cells of microvessels. They are intimately associated with endothelial cells and communicate with them via direct physical contact or through paracrine signaling pathways. These ...
Factors influencing splanchnic microcirculation in animal models of endotoxaemia
(2011-04-20)
Even though severe sepsis and septic shock therapy has improved in recent years, mortality remains high (22-50%). Disturbances in splanchnic organ homeostasis and increases in gut permeability have long been presumed to ...
Flux of cholesterol, oxysterols and plant sterols across the blood-brain barrier and metabolic consequences
(2016-10-06)
Brain is the cholesterol-richest organ and contains one fourth of the total body cholesterol. The majority of brain cholesterol is present in myelin that forms myelin sheathes around neuronal axons. This large pool of ...
New potential targets in medulloblastoma therapy : studies on cellular mechanisms and mediators
(2010-01-15)
Medulloblastoma is an embryonal tumour that mainly affects children. It
is the most common malignant brain tumour in children and accounts for
15% of all childhood brain tumours. It most often presents in the
cerebellum ...
HMGB1 in inflammation : secretion and function
(2008-11-07)
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised
by progressive joint destruction. The inflammatory and joint destructive
processes in RA are mediated by resident synovial cells and cells
recruited ...