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Studies on pericytes in health and disease
(2010-05-21)
Pericytes are the perivascular mural cells of microvessels. They are intimately associated with endothelial cells and communicate with them via direct physical contact or through paracrine signaling pathways. These ...
Functional characterization of cytosolic and mitochondrial thioredoxin reductases
(2006-09-15)
Mammalian thioredoxin reductases (TrxRs) are homodimeric selenoproteins belonging to the nucleotide oxidoreductase family. They contain a C-terminal penultimate selenocysteine residue, which is kept reduced by the N-terminal ...
Exploring thioredoxin reductase as an anticancer drug target
(2009-09-18)
Mammalian thioredoxin reductase (TrxR; EC 1.8.1.9) is a homodimeric NADPH-dependent selenium-containing flavoenzyme with disulfide oxidoreductase activity. The mammalian thioredoxin (Trx) system exerts an impressive spectrum ...
Mesh in hernia surgery : aspects on recurrence and pain of different mesh types in groin hernia repair and mesh repair in small umbilical hernias
(2021-11-04)
The groin hernia repair is one of the most common surgical procedure in Sweden with nearly 16,000 repairs performed annually. Including a mesh has become standard in the repair and the type of material and weight can ...
Factors of importance for labor induction
(2018-09-14)
Background: What initiates the onset of labor is still not clarified, and it is debated whether expectant or active management is the best for the woman and the fetus. Active management means induction of labor (IOL) which ...
Intricate aspects of the thioredoxin system in redox signaling
(2014-05-02)
Reversible modifications of redox sensitive protein thiols by reactive oxygen and nitrogen species have emerged as a major posttranslational mechanism that affects the function of the respective proteins and therewith all ...