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Biological determinants of HIV infection : studies of viral evolution during disease progression in children and adults
(2000-02-04)
Coreceptor usage of primary HIV-1 isolates was analysed in relation to their biological phenotype and the severity of HIV-1 infection in the patient. The indicator cell lines, U87 glioma cells engineered to express CD4 and ...
Studies on the mechanism of regulation of bile acid synthesis in humans with some aspects on genetic factors
(2005-10-28)
In the present investigation we studied human bile acid synthesis and its regulation both in vivo and in vitro and also evaluated a possible influence of polymorphisms in the CYP7A1 and CYP8B1 genes on bile acid synthesis ...
X-chromosome upregulation is driven by increased burst frequency
(2020-05-12)
Ohno's hypothesis postulates that X-chromosome upregulation rectifies X-dose imbalance relative to autosomal genes, present in two active copies per cell. Here we dissected X-upregulation into kinetics of transcription, ...
New insights on type 2 immunity key drivers : mast cells and group 2 innate lymphoid cells
(2019-02-22)
Type 2 immune responses are characterized by the production of cytokines IL-4, IL-5 and IL-13. They are known to have crucial physiological and pathophysiological functions in the body. Data from recent studies indicate ...