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X-chromosome upregulation is driven by increased burst frequency
(2020-05-12)
Ohno's hypothesis postulates that X-chromosome upregulation rectifies X-dose imbalance relative to autosomal genes, present in two active copies per cell. Here we dissected X-upregulation into kinetics of transcription, ...
Telomerase in hematological and other malignancies : therapeutic implications
(2015-11-05)
The Telomere is a nucleoprotein complex consisting of TTAGGG repeated sequences covered by specialized binding proteins termed shelterins masking the end of linear chromosomes and thereby protecting the end of the chromosome ...
Transcriptome studies of cell-fate and aging
(2005-04-22)
Microarrays enable the researcher to capture the expression levels from most genes in a single experiment. The methodology has opened up a new field with possibilities and challenges. This thesis focuses on both methodological ...