Search
Now showing items 1-9 of 9
Cytokines in rheumatoid arthritis
(2000-01-21)
Rheumatoid arthritis (RA) is a chronic systemic disease characterised by inflammation in several joints. Cytokines appear to be important as both disease promoting and disease- suppressing mediators in the disease. The use ...
Congenital CMV infection and connexin 26 mutations in childhood deafness : intervention with early cochlear implantation
(2013-11-22)
Hearing impairment (HI) is a common disability, which affects a significant proportion of the population. Early in life, however, the risk of acquiring a HI is low, with 0.2 % of all newborns having a permanent HI, and of ...
Regulation of insulin-like growth factor-1 receptor expression and signaling
(2007-05-25)
Insulin-like growth factor-1 receptor (IGF-1R), a member of the insulin
receptor tyrosine kinase family is a broadly expressed transmembrane
receptor that plays a key role in malignant cell growth. IGF-1R transmits
information ...
Studies of specific immunity against viral infections in patients after stem cell transplantation
(2007-10-12)
Recipients of allogeneic hematopoietic stem cell transplantation
(allo-HSCT) experience a prolonged period of immune deficiency, resulting
in significant morbidity and mortality from the infections. Viruses such
as ...
Thioredoxin and glutaredoxin systems under oxidative and nitrosative stress
(2017-03-16)
Our knowledge about reactive oxygen species (ROS) and reactive nitrogen species (RNS) has been changed from simple damaging molecules to redox signaling mediators. ROS/RNS mediated signaling is mainly based on the reversible ...
Human cytomegalovirus in congenital infections and embryonal malignancies of the nervous system
(2009-10-02)
Cytomegalovirus (CMV) is a herpesvirus that may cause severe or even fatal disease in immunocompromised patients as well as severe developmental disturbances in foetuses infected in utero. In contrast, only mild symptoms ...
Infection early in life and risk of non-affective psychosis
(2015-04-07)
In light of the increasing, but insufficient, evidence that various infections and immunological processes during brain development are associated with psychotic disorder, the aim of this thesis was to investigate infection ...
IGF-1R inhibition : a tool for functional studies of insulin-like growth factor family in malignant cells
(2006-01-13)
Cancer cells generally posses the capability of overusing normal extracellular signaling for proliferation and/or anti-apoptosis to create growth advantage over the normal cells. Major players in extracellular signaling ...
Environmental and lifestyle factors, including viral infections, in relation to development of allergy among children in Saint-Petersburg and Stockholm
(2007-09-07)
The increasing prevalence of allergic diseases in children, particularly noteworthy in developed countries, has become an object of international concern. A lack of exposure to a broad range of infectious agents in early ...