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Mathematical modeling of fluid and solute transport in peritoneal dialysis
(2001-01-24)
Optimization of peritoneal dialysis schedule and dialysis fluid composition needs, among others, methods for quantitative assessment of fluid and solute transport. Furthermore, an integrative quantitative description of ...
Gene expression profiling in animal models of alcoholism
(2004-11-24)
Genetic and environmental factors in alcoholism interact at the level of the transcriptome to encode the phenotypic traits of this complex clinical syndrome. Because of this, the prospect of simultaneous, genome wide, ...
Thioredoxin and glutaredoxin systems under oxidative and nitrosative stress
(2017-03-16)
Our knowledge about reactive oxygen species (ROS) and reactive nitrogen species (RNS) has been changed from simple damaging molecules to redox signaling mediators. ROS/RNS mediated signaling is mainly based on the reversible ...
Perinatal regenerative medicine : development of autologous constructs for soft tissue defects
(2018-03-26)
Disrupted organogenesis leads to permanent malformations that may require surgical correction. Affected new-borns without spare tissue for the primary closure are dependent of other solutions. Because of the perinatal ...
From nucleus to mitochondria : a ubiquitination study
(2019-01-18)
Ubiquitination is a post-translational modification achieved by an enzymatic cascade. This post-translational modification is involved in many crucial cellular processes across different cellular compartments such as protein ...
Flux of cholesterol, oxysterols and plant sterols across the blood-brain barrier and metabolic consequences
(2016-10-06)
Brain is the cholesterol-richest organ and contains one fourth of the total body cholesterol. The majority of brain cholesterol is present in myelin that forms myelin sheathes around neuronal axons. This large pool of ...
Improving immunogenicity of hepatitis B and C viral proteins for vaccine design
(2010-05-14)
The hepatitis B and C virus (HBV, HCV) both presents a global health challenge, with an estimated 350 million individuals chronically infected with HBV and over 200 million infected with HCV. Reported cases of HBV and HCV ...
Abnormal coagulation and platelet function in patients with severe traumatic brain injury
(2016-03-22)
Traumatic brain injury (TBI) is associated with a high mortality and severe long-term morbidity in
survivors. TBI often affects previously healthy young persons, and represents one of the most
common causes of death among ...
Innate mechanisms regulating B cell activation in inflammatory diseases
(2010-11-18)
Generation of powerful and highly specific immune responses against invading pathogens is essential to our survival. However, the immune system can cause disease if activated in an inappropriate manner. Examples include ...
Characterization of malignant pleural mesothelioma : possibilities for an individualized therapeutic arsenal
(2014-01-28)
Less than 50% of malignant mesothelioma patients respond to standard chemotherapy treatment and there is a great need to identify these patients, and find their best treatment options. The aim of this thesis was to increase ...