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The role of neuropeptides in spinal nociceptive mechanisms with special emphasis on galanin, neuropeptide Y and orphanin FQ/nociceptin
(2000-01-21)
Several peptides present in sensory neurons and in the spinal cord have been recognized to have inhibitory action in nociception. In this thesis, we have used the flexor reflex preparation in rats to study the role of ...
Mitochondria and cellular energy metabolism in platinum chemotherapy
(2009-09-18)
Chemotherapy is a major strategy in the treatment of cancer. Unfortunately, treatment of advanced cancers often fails due to tumor resistance to chemotherapeutic drugs. Studies of cell death signaling induced by chemotherapeutic ...
Redox-regulation of PTPs : mechanisms and impact on PDGFR signaling
(2013-05-23)
Protein tyrosine phosphatases (PTPs) are reversibly oxidized upon activation of platelet-derived growth factor receptor beta (PDGFβR). Dys-regulation of the PDGFβR signaling pathway is associated with several diseases, ...
Vascular remodeling in pulmonary hypertension
(2015-05-22)
Pulmonary hypertension (PH) is a progressive obliterative vasculopathy with multifactorial etiology and high mortality rate. Endothelial dysfunction, excessive vascular remodeling, inflammation and in situ thrombosis ...
Tumor-mediated changes in the immune system of cancer patients : a balancing act between suppressors and effectors
(2011-10-25)
Tumors and immune cells interact in many ways: immune cells can recognize and even kill tumor cells, while the tumor on the other hand can induce cells of the immune system to participate in tumor-mediated immune ...
Airway protection and coordination of breathing and swallowing : in health and anesthesia
(2013-10-17)
Swallowing and breathing is coordinated to ensure that the airway is protected from aspiration. During the pharyngeal phase of swallowing, breathing is interrupted to allow safe passage of bolus. However, details on the ...
Pharmacoepidemiology and health economics of adherence to pharmaceutical fracture prevention
(2020-04-06)
Background: Osteoporosis is a disease characterized by weak bone, affecting hundreds of millions of people worldwide, predominantly postmenopausal women. The main clinical consequence of the disease is bone fractures and ...
Aspects of arterial wall healing : re-endothelialization, intimal hyperplasia and vascular remodeling
(2019-05-08)
Cardiovascular disease is the leading cause of mortality in the world. Despite prevention, the need for interventions remains high. Patients with type 2 diabetes mellitus have an increased cardiovascular burden and are at ...
Prevalence of dentinogenesis imperfecta and dental aberrations related to genetic findings in osteogenesis imperfecta
(2018-05-04)
Osteogenesis imperfecta (OI) is a clinically and genetically heterogeneous connective tissue disorder, mainly caused by mutations in COL1A1 and COL1A2, the genes encoding collagen type I. The cardinal symptoms include bone ...
Infection early in life and risk of non-affective psychosis
(2015-04-07)
In light of the increasing, but insufficient, evidence that various infections and immunological processes during brain development are associated with psychotic disorder, the aim of this thesis was to investigate infection ...