Search
Now showing items 1-10 of 11
Genomic studies of expanded trinucleotide repeats : focus on neuropsychiatric disorders
(1998-08-14)
In a number of neurological and neuropsychiatric disorders, a worsening of the disease phenotype from one generation to the next has been linked to expanded trinucleotide repeat sequences that increase in size upon ...
Persistent Helicobacter pylori infection and host response
(2010-05-21)
Helicobacter pylori persistently colonizes the gastric mucosa of approximately one half of the world's population. Colonization always leads to chronic gastric inflammation, which may progress to peptic ulcer disease, ...
Modulation of nuclear receptor function by interacting proteins
(2007-08-21)
Nuclear receptors are a family of transcription factors involved in many
biological processes. They represent key potentials as therapeutic
targets for several clinical conditions such as diabetes, obesity,
cardiovascular ...
Musculoskeletal injuries and generalized joint laxity in ballet dancers
(2012-09-13)
Aims: To examine the incidence and type of musculoskeletal injuries in classical ballet dancers, to analyse these injuries in relation to absence from performance, and to identify dancers at risk of frequent injuries in a ...
Studies of b-AP15 : a novel inhibitor of proteasome deubiquitinase activity
(2017-04-07)
Bortezomib was the first FDA approved proteasome inhibitor that was initially very successful in treatment of multiple myeloma patients but acquired resistance and adverse side-effect highly decreased patients’ quality of ...
The role of the RNA-binding protein Wig-1 in post-transcriptional regulation of gene expression
(2014-10-17)
The p53 transcription factor is activated by cellular stress. This triggers transcriptional activation of a number of p53 target genes, leading to responses such as cell cycle arrest and/or induction of apoptosis. Wig-1 ...
Analysis of global gene expression in complex biological systems using microarray technology
(2006-01-06)
The general aim of this thesis has been to explore the use of Affymetrix microarray technology in studies of global gene expression in complex biological systems, particularly with regard to the dynamics and heterogeneity ...
Genetic and pathophysiological study of desmin derangements in cardiac disorders
(2007-08-23)
Desmin is a chief intermediate filament of skeletal and cardiac muscle. Its main function is to provide structural and functional integrity to the cell and to transmit tension along the myofibrils, protecting them from ...
Lactobacillus mediated targeting of gastrointestinal pathogens
(2014-05-20)
The mucosal membranes of the gastrointestinal, genitourinary and respiratory tract are the main targets for infection in the human body and are repeatedly challenged by pathogens. Passive immunization using delivery of ...
Body composition and bone mineral density in rheumatoid arthritis : influence of inflammation and treatment with glucocorticoids and TNF-blocking agents
(2009-11-20)
Rheumatoid arthritis (RA) is a chronic inflammatory disease. Besides symptoms from the joints, changes in body composition and reduced bone mineral are common. Increased fat mass (FM) and loss of muscle mass contribute to ...