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Studies on nerve terminations in human mucosa and skin
(1997-09-12)
In spite of their accessibility and important sensory function, the nervous tissue components of human oral and vaginal mucosa and skin have been subject to very few, if any, systematic investigations. Studies on the ...
Two novel combination therapies of glioblastoma multiforme from a Cx43 perspective : studies of in vitro models
(2008-03-28)
The group of patients suffering from the malignant brain tumour
glioblastoma multiforme (GBM) have a median survival of only about one
year. Thus, new treatment strategies are urgently needed.
Gap junctions are ...
Exercise as treatment for depression
(2016-10-06)
Studies have reported that physical activity can be protective against developing depression and that exercise can be as effective as pharmacotherapy or psychotherapy in the treatment of depression. However less is known ...
Clinical and genetic stratification of childhood psoriasis
(2015-04-29)
Psoriasis is a clinically heterogeneous and common disease affecting about 2-3% of the
population in Sweden. Twin and family studies have shown a strong and complex genetic
background in psoriasis. The strongest known ...
Acute intermittent porphyria : studies of chronic disease, recombinant enzyme therapy and late complications
(2008-10-17)
This thesis comprise five studies on patients with acute intermittent porphyria (AIP) observed under different clinical conditions associated with the disorder. They have generally been monitored at the porphyria out-patient ...
Genomic DNA methylation in health and disease
(2009-01-23)
Cytosine methylation is one of the important epigenetic mechanisms controlling the vertebrate genome. Changes in genomic DNA methylation have been demonstrated in aging, auto-immune diseases and cancer. Aberrant DNA ...
Novel aspects of neuroblastoma : to hypoxia and beyond
(2019-02-27)
Neuroblastoma (NB) is a pediatric cancer arising from the neural crest cells forming the sympathetic nervous system. Just as other types of pediatric cancer the driving mutations of neuroblastoma are few and the tumors are ...
Characterization of host and microbe interactions affecting adherence, clearance and systemic spread of S. pneumoniae
(2009-11-06)
Streptococcus pneumoniae (the pneumococcus) mainly gives rise to diseases of the respiratory tract, such as pneumonia, acute otitis media and sinusitis, but it also causes severe invasive diseases, such as meningitis and ...
Peroxisome proliferator-activated receptor delta (PPARD) : molecular studies of regulation and activation
(2011-02-02)
The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors involved in energy homeostasis. Their natural ligands are fatty acids and there are three different PPAR isoforms; PPARA, ...
Mild traumatic brain injury : antecedents and aftermath
(2019-03-08)
Mild Traumatic Brain Injury (mTBI) is a frequent, trauma-induced injury, associated with loss of consciousness and/or memory loss for the injury event. Injured individuals experience a wide range of somatic symptoms (e.g. ...