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T cell responses and NK cell function in experimental autoimmune diabetes
(2004-11-12)
The immune system is regulated by several complex mechanisms to maintain self tolerance and prevent autoimmune diseases. However, genetic as well as environmental factors can increase the risk of breaking self tolerance. ...
Regulation of the ribosomal RNA transcription by c-MYC oncoprotein
(2006-11-30)
The transcription factor c-Myc is a key regulator of growth and proliferation. c-Myc levels are tightly controlled and deregulated c-Myc is often associated with human cancers. In our initial studies we observed that upon ...
Recessive parkinsonism, mitochondria and translational regulation
(2008-09-05)
Three genes are known to cause recessive forms of Parkinson disease (PD) in humans: parkin, PINK1 and DJ-1. Of these, the rarest is DJ-1; less than fifty known cases worldwide are due to mutations in DJ-1. Though rare, ...
Functional characterization of the alternative reading frame protein p14ARF
(2004-05-06)
A deeper understanding of the molecular events underlying tumor development is a prerequisite for the design of novel and efficient therapies. Inactivation of the p53 and retinoblastoma (Rb) tumor suppressor pathways appears ...
Molecular aspects of retinol uptake and activation
(2005-11-11)
Retinoids (vitamin A derivatives) are essential for a wide variety of physiological processes, including embryonic development, growth, vision, reproduction, and maintenance of various epithelia and the immune system. ...
Expression profiling of blood vessels in pericyte deficiency and diabetes
(2010-11-11)
The kidney glomerulus is essential for the filtration of waste products from the blood into the urine and in controlling the volume and composition of body fluids. Injury to the glomerulus can lead to altered glomerular ...
ROR1 : a novel receptor tyrosine kinase with unique therapeutic potentials in chronic lymphocytic leukemia
(2011-10-13)
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of small B lymphocytes in blood, bone marrow, lymph nodes and other lymphoid tissues. CLL is the most common leukemia in the Western world. Despite ...