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Expression profiling of blood vessels in pericyte deficiency and diabetes
(2010-11-11)
The kidney glomerulus is essential for the filtration of waste products from the blood into the urine and in controlling the volume and composition of body fluids. Injury to the glomerulus can lead to altered glomerular ...
Effects of Alzheimer's and Parkinson's disease gene mutation on cell signaling
(2009-01-09)
Alzheimer's disease (AD) and Parkinson's disease (PD) are the major
neurodegenerative disorders affecting the elderly. The discovery of genes
causing familial forms of these disorders has contributed enormously
towards ...
A study of b-secretase cleaved Alzheimer amyloid precursor protein
(2002-04-05)
Alzheimer's disease (AD) is characterized by the degeneration and loss of neurons, intracellular neurofibrillary tangles and the accumulation of extracellular senile plaques consisting mainly of beta-amyloid (A-beta). ...
Perinatal regenerative medicine : development of autologous constructs for soft tissue defects
(2018-03-26)
Disrupted organogenesis leads to permanent malformations that may require surgical correction. Affected new-borns without spare tissue for the primary closure are dependent of other solutions. Because of the perinatal ...
Studies on the gamma-secretase complex and processing of the Alzheimer's disease-associated amyloid precursor protein
(2004-03-26)
Alzheimer's disease (AD) is a devastating neurodegenerative disorder that
causes the most common form of dementia. Pathological lesions, such as
plaques consisting of the amyloid beta-peptide (Ab), are found in the
brains ...
Amyloid precursor protein with the Alzheimer´s disease 670/671 mutation : animal and cellular models
(2008-10-03)
The amyloid precursor protein (APP) and it s derivatives play a key role
in the pathogenesis of Alzheimer s disease (AD), which is characterized
by the presence of multiple aggregates of an APP proteolytic product, ...
Inflammation as a therapeutic target for Alzheimer's disease
(2010-04-02)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder
which is characterised by impairment of memory and learning. The
impairment is caused by neuronal death which originates in the parts of
the brain ...