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Born too small or too early : effects on blood pressure, renal function and retinal vascularization in adulthood : experimental and clinical studies
(2004-11-12)
Background: Several epidemiological studies the past fifteen years have
suggested a connection between fetal growth retardation and later effects
on adult health, such as an increased arterial blood pressure and type ...
Two novel combination therapies of glioblastoma multiforme from a Cx43 perspective : studies of in vitro models
(2008-03-28)
The group of patients suffering from the malignant brain tumour
glioblastoma multiforme (GBM) have a median survival of only about one
year. Thus, new treatment strategies are urgently needed.
Gap junctions are ...
Guinea pig osteoarthrosis : morphological and biochemical studies
(1999-02-04)
Hartley guinea pigs spontaneously and reproducibly develop an arthropathy mimicking human primary osteoarthrosis. The morphological lesions first appear between 6 and 12 months of age, when it is confined to the ...
The effect of Gal alpha(1,3)gal glycopeptide-conjugates and human serum on HIV-1 infection and replication
(2012-10-23)
The first step in the entry of HIV-1 is the binding of the viral envelope glycoprotein (gp120) to the CD4 molecule expressed mainly on T helper cells. Upon binding, gp120 undergoes a series of conformational changes that ...
Optimization of suicide gene therapy in stem cell transplantation with special reference to the selection marker OuaSelect
(2009-04-22)
For many patients suffering from leukemia and other hematological malignancies, allogeneic hematopoietic stem cell transplantation (HSCT) represents the only curative approach. However, an optimal HSCT procedure is yet to ...
Functional studies of anti-gpi monoclonal antibodies and anti-citrullinated protein antibodies (ACPAS)
(2023-05-11)
RA is an autoimmune disease that primarily impacts joints throughout the body. The disease can result in pain, stiffness, and reduced mobility. It is a chronic disease, meaning that it lasts a long time and can worsen over ...
Role of GPS2 in epigenome alterations linked to metaflammation
(2018-10-18)
Current evidence suggests that transcriptional and epigenomic reprogramming events, triggered by transcription factors and chromatin-modifying co-regulators, are of central importance for disease development. G-protein ...
Studies on molecular regulation of inflammation in cutaneous lupus erythematosus
(2011-03-24)
Lupus erythematosus (LE) is an autoimmune disease with a wide range of clinical manifestations. This spectrum spans from limited cutaneous disease to life-threatening rheumatic disorder involving vital organs. Sun exposure ...
Stress, sleep, and allergy
(2010-10-15)
Allergic diseases have recently increased dramatically in the western
world, now affecting about 30% of the Swedish population. The reasons for
this increase are unclear, but some of the suspects are behavioral
factors, ...
Mechanisms of multicellular drug resistance and novel approaches for targeted therapy in cancer
(2019-01-24)
Dysregulated gene expression, due to genetic and epigenetic aberrations, as well as cancer cell-stroma interactions underlie both tumorigenesis and resistance to anti-cancer therapy. Although governed by common mechanisms, ...