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Neurotrophic and immune regulatory factors in neuroinflammation
(2004-10-22)
Inflammatory reactions in the nervous system act as a double-edged sword.
On the one hand, neuroinflammation can have very devastating effects on
the nervous system, leading to neurological dysfunction. Conversely,
there ...
Dietary prevention of gastrointestinal cancer : epidemiologic studies of fruit, vegetables and cereals
(2000-12-22)
The widely accepted inverse associations between fruit, vegetables,
dietary fiber and colorectal cancer risk, have recently been called into
question. In addition, dietary studies of certain cancers, such as
adenocarcinomas ...
Pregnancy related risk factors for breast cancer
(2003-12-19)
Pregnancies offer a life-long reduction in breast cancer risk. It has
repeatedly been shown that both number of pregnancies and age at first
birth affect the future breast cancer risk. The mechanisms for this
protection ...
Regression on high-dimensional predictor space : with application in chemometrics and microarray data
(2004-11-26)
This thesis focuses on regression methodology for prediction and
classification in situations where there are many predictors but limited
number of observations. This situation is common in chemometrics and
microarray ...
Statistical genetic analysis of family data
(2008-08-22)
The importance of genetic determinants and risk factors of diseases has been consistently recognized in genetic epidemiology, which is one of the fastest growing areas in genomic medicine. Familial clustering is a common ...
Exploring statistical models for estimating remaining life years & loss in life expectancy for cancer patients
(2024-03-08)
As advancements in cancer prognosis and treatment continue for many cancer types, there is a growing interest in estimating survival over longer time periods. The assessment of the years remaining after a cancer diagnosis, ...
Genetic studies of depressive symptoms
(2004-02-06)
This thesis is focused on depressive symptoms particularly in late fife. Depressive symptoms are associated with serious negative outcomes a greater level of disability and with excess morbidity and mortality. This thesis ...
Genetic susceptibility to breast and endometrial cancer
(2004-09-10)
Hormones are central in the carcinogenic process in the breast and in the uterine epithelium. Individual genetically determined variation in the response to hormonal influence may alter susceptibility to breast and endometrial ...
New evidence on germ-cell testicular cancer aetiology
(2004-01-09)
Testicular cancer has been increasing in incidence for at least 50 years in many populations, but its etiology remains elusive. We investigated several prenatal and postnatal factors in association with germ-cell testicular ...