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Pregnancy related risk factors for breast cancer
(2003-12-19)
Pregnancies offer a life-long reduction in breast cancer risk. It has
repeatedly been shown that both number of pregnancies and age at first
birth affect the future breast cancer risk. The mechanisms for this
protection ...
Serine / threonine protein phosphatase 5 – a double-edged sword : in the progression towards diabetes
(2012-05-15)
Type 2 diabetes mellitus is increasing at an alarming rate worldwide. In the development and progression of type 2 diabetes mellitus, the insulin-producing pancreatic β-cells are commonly exposed to a hyperglycemic and ...
Comorbidity and mortality in Prader-Willi syndrome
(2021-11-30)
Background: Prader-Willi syndrome (PWS) is a multisymptomatic, rare, genetic, disorder, due to lack of the expression of paternal genes in the q11-q13 region of chromosome 15. The main characteristics of PWS are muscular ...
Diabetogenic effects of glucocorticoids : role of protein phosphatase 5 and GLP-1 receptor activation
(2014-02-28)
Obesity, the metabolic syndrome and type 2 diabetes are inextricably linked together, and all increase with rapid pace globally. Glucocorticoid (GC) excess is associated with diabetogenic effects, including insulin resistance ...