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New evidence on germ-cell testicular cancer aetiology
(2004-01-09)
Testicular cancer has been increasing in incidence for at least 50 years in many populations, but its etiology remains elusive. We investigated several prenatal and postnatal factors in association with germ-cell testicular ...
On the role of notch, numb and numblike in development and cancer
(2007-12-28)
The development of mutlicellualr organisms relies on a highly conserved signaling network, of which one of the key components is the Notch signaling pathway. The core Notch signaling pathway consists of receptors, ligands ...
Determination and use of radiobiological response parameters in radiation therapy optimization
(2001-11-23)
Optimization of radiation therapy is critically dependent on the use of patient related information. For this reason, radiobiological models describing the dependence of tumour and normal tissue responses on the irradiated ...
p16INK4A and p15INK4B in senescence, immortalization and cancer : gene transfer by adenovirus vectors
(2001-11-09)
The astrocytic gliomas are the most common form of brain tumors in
humans. The malignant progression from low grade (astrocytoma, grade II)
to high-grade (glioblastoma multiforme, grade, IV) astrocytomas is well
documented ...