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Deciphering mechanisms of transcriptional activation and repression in B lymphocytes
(2004-05-14)
During the course of evolution, our immune system has developed, to defend us against infections, a diverse number of specialized cell types. Immunoglobulin producing B lymphocytes are produced by the differentiation of ...
Regulation of transcription factors by XAP-2 : a member of the Hsp90 chaperone complex
(2008-08-29)
The AhR belongs to the bHLH/PAS family of transcription factors, which
mediates biological effects of environmental pollutants such as
2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD). In the absence of ligand
the AhR is ...
Regulation of gene transcription by the thyroid hormone receptors
(2006-05-26)
Thyroid hormone (TH) has important effects on postnatal development as well as on adult metabolic homeostasis. TH meditates its effects through different isoforms of the thyroid hormone receptors (TRs) encoded by the TRalpha ...
Ah receptor mediated toxicity : studies in vitro and in a transgenic mouse model
(2007-02-01)
The polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls are ubiquitously present in the environment. Humans are exposed mainly through diet to continuous low levels which on average are in close proximity to ...
Influence of oxidative stress on aryl hydrocarbon receptor signaling
(2013-05-13)
The aryl hydrocarbon receptor (AHR), a multifunctional protein and a key regulator of drug metabolizing enzymes, belongs to the basic-helix-loop-helix (bHLH)/PAS (Per-Arnt-Sim) super-family of transcription factors. The ...
A 10-year follow-up of people with multiple sclerosis-aspects of disability and health, use of and satisfaction with care, and feasibility of cognitive behavioural therapy
(2014-11-21)
Background: Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease in the central nervous system which affects a number of life areas of the afflicted individual. Detailed knowledge is required on ...
Functional role of a constitutively active dioxin/Ah receptor in a transgenic mouse model
(2003-02-13)
The dioxin/ Aryl hydrocarbon receptor is a ligand-activated transcription factor that mediates most (if not all) of the toxic effects of the group of highly potent environmental pollutants collectively called dioxins and ...
Dynamic regulation of aryl hydrocarbon receptor function and activity by different stimuli
(2010-03-26)
Cells have to sense and adapt to changes in their surrounding environment. Most of the cellular responses to environmental and developmental stimuli are mediated by PAS (Per-ARNT-Sim) proteins. A member of this family of ...