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Regulation of transcription factors by XAP-2 : a member of the Hsp90 chaperone complex
(2008-08-29)
The AhR belongs to the bHLH/PAS family of transcription factors, which
mediates biological effects of environmental pollutants such as
2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD). In the absence of ligand
the AhR is ...
Molecular mechanisms underlying the oncogenic function of SS18 and SSX
(2008-01-04)
The SS18 and SSX genes were initially identified based on their
reoccurrence as fusion partners in synovial sarcoma. As a result of the
specific chromosomal translocation t(X:18), the SS18 gene from chromosome
18 becomes ...
Identification and validation of therapeutic targets in sarcoma models
(2009-05-21)
In spite of the low incidence of sarcomas, they are highly aggressive tumors, with high metastatic potential, and resistance to both chemotherapy and radiotherapy, leaving surgery as the only treatment option. There is ...
Regulation of gene expression by non-protein-coding RNAs
(2009-01-29)
The human genome sequencing projects revealed that the human genome contains over 3 billion DNA base pairs, but only 20,000 25,000 protein-coding genes. In fact, only about 1.2% of the genome codes for proteins. Surprisingly, ...