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Hereditary colorectal cancer : predisposition and prevention
(2004-01-23)
This thesis focuses on the clinical results from a ten-year long
follow-up surveillance program, including regular colonoscopy, for
subjects (n=304, 780 colonoscopies) with increased risk of colorectal
cancer, and on ...
HLA predisposition to human papillomavirus induced cervical neoplasia : population based studies from the Västerbotten county in northern Sweden
(2001-08-08)
Infection with human papillomaviruses (HPV) types 16 and 18 is the major
cause of cervical neoplasia. Although a high proportion of cervical
cancers (CXCA) harbor HPV genomes, only a small number of women infected
with ...
Factors influencing the metabolism of inorganic arsenic in humans
(2007-05-11)
Inorganic arsenic (iAs), a naturally occurring drinking water contaminant, is a potent human carcinogen and toxicant. It is believed that in humans, as well as in most mammals, inorganic arsenic is biotransformed via ...
Anthracycline pharmacodynamics and pharmacokinetics in acute myeloid leukemia
(2010-11-05)
The goal of this thesis has been to study pharmacodynamics and pharmacokinetics of anthracyclines in acute myeloid leukemia (AML) with the ultimate goal to improve chemotherapy:
1. By studying the relation between ...
The impact of vascular structure and function on tumor growth, retinopathy, and antiangiogenic therapy
(2011-08-22)
Tumors produce multiple angiogenic factors to stimulate neovascularization that is essential for tumor growth, invasion and metastasis. Despite the known angiogenic functions of each individual factor, the interplay between ...
Dementia and use of drugs : economic modelling and population-based studies
(2015-01-30)
The overall aim of this thesis was to investigate epidemiological and health economic aspects
of dementia and drug use in older people, through economic modelling and analyses of
population-based studies. The major ...
Nitric oxide in brain contusion
(2005-05-13)
Trauma to the brain is a leading cause of death and disability. The primary injury initiates a cascade of biochemical reactions in the brain that causes further neuronal damage, a process referred to as secondary brain ...
Studies on the presence and influence of human papillomavirus (HPV) in head and neck tumors
(2005-03-18)
The aim of this thesis was to confirm the presence of human papillomavirus (HPV) in tonsillar cancer and the previous finding that presence of HPV in tonsillar cancer is prognostic favorable for patient survival. Furthermore, ...
Integrated assessment of environmental and human health risks of antibiotic residues and resistance for environmental and health policy
(2021-04-27)
Background: Antibiotic resistance is a global health crisis and a serious threat to progress in achieving the Sustainable Development Goals. This requires a One Health response that recognises the link between human and ...
Systemic lupus erythematosus : biomarkers and biologics
(2017-01-26)
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, predominantly affecting women of childbearing age. The pathogenesis of SLE is multifactorial, and the clinical phenotype and course vary considerably ...