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Gene regulation mechanisms by the transcriptional coregulator mastermind-like 1
(2009-03-27)
MAML1 was first identified as a coactivator for Notch receptors, but later it was also found to function as a coactivator for several other activators, including p53, beta-catenin, and MEF2C. MAML1 is critical for Notch ...
Anthracycline pharmacodynamics and pharmacokinetics in acute myeloid leukemia
(2010-11-05)
The goal of this thesis has been to study pharmacodynamics and pharmacokinetics of anthracyclines in acute myeloid leukemia (AML) with the ultimate goal to improve chemotherapy:
1. By studying the relation between ...
A study of b-secretase cleaved Alzheimer amyloid precursor protein
(2002-04-05)
Alzheimer's disease (AD) is characterized by the degeneration and loss of neurons, intracellular neurofibrillary tangles and the accumulation of extracellular senile plaques consisting mainly of beta-amyloid (A-beta). ...
Role of posttranslational modifications in regulation of Notch and transcriptional coactivator mastermind-like 1
(2011-12-29)
The Notch signaling is an evolutionary conserved pathway enabling short range cell-cell interactions, crucial for diverse developmental and physiological processes during embryonic and adult life. The Mastermind-like (MAML) ...
Inhibition of 19S proteasome deubiquitinases as a promising strategy in cancer therapy
(2017-04-28)
The ubiquitin proteasome system (UPS) is the main degradation system in the eukaryotic cell and it is involved in the regulation of many crucial cellular pathways; such as signal transduction, proliferation, DNA repair, ...
Amyloid precursor protein with the Alzheimer´s disease 670/671 mutation : animal and cellular models
(2008-10-03)
The amyloid precursor protein (APP) and it s derivatives play a key role
in the pathogenesis of Alzheimer s disease (AD), which is characterized
by the presence of multiple aggregates of an APP proteolytic product, ...
Biomechanical and morphological aspects of abdominal aortic aneurysm growth and rupture
(2023-04-05)
Abdominal aortic aneurysms (AAAs) are dilatations of the abdominal aorta that pose a risk of rupture. The only effective treatment is intervention prior to rupture, but this is also associated with mortality and morbidity. ...