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Plasticity of the dopamine1 receptor and its signaling pathway
(2003-09-12)
Dopamine 1 receptor (D1R) belongs to the G protein coupled receptor superfamily with seven transmembrane domains. Previous studies from our laboratory showed that D1R availability in the plasma membrane of renal epithelial ...
Bicuspid aortic valve-associated aortopathy unraveling the molecular signature
(2013-05-22)
Patients with bicuspid aortic valve (BAV) have an increased risk of developing ascending aortic aneurysm compared with individuals with a tricuspid aortic valve (TAV). A crucial factor involved in vascular remodeling during ...
Extracellular matrix-mediated signaling in the regulation of vascular smooth muscle cell phenotype and function
(2001-08-10)
Cardiovascular disease is the leading cause of mortality in the world. Even though death rates are today dropping in the developed countries, disability due to the disease is rising worldwide. The major portion of ...
Role of innate cellular immunity in the immunopathogenesis of HIV-1 infection in Uganda
(2016-11-17)
The global epidemic of HIV has resulted in more than 34 million deaths and currently 36.9 million HIV-infected people worldwide. Uganda has an HIV prevalence of 7.3%, equating to about 1.6 million people. This has placed ...