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Bicuspid aortic valve-associated aortopathy unraveling the molecular signature
(2013-05-22)
Patients with bicuspid aortic valve (BAV) have an increased risk of developing ascending aortic aneurysm compared with individuals with a tricuspid aortic valve (TAV). A crucial factor involved in vascular remodeling during ...
Pharmaceutical insights into improving oligonucleotide delivery and efficacy
(2021-08-13)
The power of gene therapy lies in their capacity to target a disease on a genetic level. Nucleic acid containing therapeutics can be utilized to treat, diagnose or prevent a possible disease or condition. However, the ...
Computational and chemical approaches to drug repurposing
(2023-08-31)
Drug repurposing, which entails discovering novel therapeutic applications for already existing drugs, provides numerous benefits compared to conventional drug discovery methods. This strategy can be pursued through two ...
The kynurenine pathway in body and brain : relation with physical exercise and mental health
(2021-04-29)
The kynurenine pathway of tryptophan degradation is the focus in a variety of research fields and several of the metabolites produced along the pathway are suggested as future biomarkers. Growing interest in a better ...
Identification of novel modulators of protein synthesis and nucleolar biology using high throughput phenotypic screens
(2022-02-23)
Protein synthesis and ribosome biogenesis are fundamental steps in gene expression and constitute the most energy demanding processes in living cells. Dysregulation of these processes is associated to a variety of human ...
Plurifaceted proteomics in studying cellular dynamics and action mechanisms of anticancer drugs
(2021-05-05)
Mass spectrometry (MS)-based proteomics has developed tremendously in recent years and was the leading technology for many novel methods to study protein chemistry. Contrary to classical approaches based on Western blot, ...
Responsive nanostructured materials for bioanalyte detection and triggered antimicrobial therapy
(2022-04-29)
Inorganic nanomaterials are attractive candidates for biomedicine as they can offer increased stability including light, temperature and chemical stability while also offering the benefits of high-throughput synthetic ...
Understanding allergies : how infections affect the function of T helper cells
(2022-11-24)
Allergic disorders are caused by a combination of hereditary and environmental factors. The hygiene hypothesis postulates that early-life microbial exposures impede the development of subsequent allergic diseases. However, ...
Targeting stromal components in the tumor microenvironment for cancer therapy
(2022-12-20)
In the tumor microenvironment (TME), different cell components crosstalk with each other
through various growth factors, cytokines, chemokines, and enzymes. They offered crucial
survival signals for tumor cell proliferation ...
Multiple sclerosis : from genetic variants to biomarkers
(2019-09-06)
Multiple sclerosis (MS) is a common chronic autoimmune and neurodegenerative disease of the central nervous system (CNS). MS is a debilitating disease that affects young adults, especially females. Why we develop MS? Is ...