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Variable viral genes as genetic immunogens
(2003-01-17)
Influenza and HIV-1 are two highly variable viruses that cause extensive morbidity and mortality in many countries. The most cost-effective medical intervention against influenza is vaccination but this has to be repeated ...
Hormonal and paracrine influences on Leydig cell steroidogenesis
(2006-08-18)
Androgen production by Leydig cells is critical for development of the male reproductive organs and for maintaining normal body homeostasis and fertility later in life. Biosynthesis of testosterone is driven by secretion ...
Evaluation of biomarkers in chronic inflammatory diseases
(2020-05-20)
The overall aim of this thesis was to assess the role of biomarkers in chronic inflammatory disease. The goal of the first study was to investigate the association of sIL-6R and sgp130 levels and risk of first myocardial ...
Interleukin 6 trans-signalling : cardiovascular risk marker or therapeutical target?
(2020-02-14)
Background: Interleukin (IL) 6 signals in two pathways. In classical signalling, essential in antimicrobial defence and tissue regeneration, IL6 binds the membrane-bound IL6 receptor (IL6R) which associates with the signal ...
Exploring the transcriptome of the brain
(2014-05-14)
Our knowledge of the transcriptome has become much more complex since the days of the central dogma of molecular biology. We now know that splicing takes place to create potentially thousands of isoforms from a single gene, ...