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Exploring the transcriptome of the brain
(2014-05-14)
Our knowledge of the transcriptome has become much more complex since the days of the central dogma of molecular biology. We now know that splicing takes place to create potentially thousands of isoforms from a single gene, ...
Recessive parkinsonism, mitochondria and translational regulation
(2008-09-05)
Three genes are known to cause recessive forms of Parkinson disease (PD) in humans: parkin, PINK1 and DJ-1. Of these, the rarest is DJ-1; less than fifty known cases worldwide are due to mutations in DJ-1. Though rare, ...
Origin of intraradicular infection with Enterococcus faecalis in endodontically treated teeth
(2015-05-13)
The reported prevalence of Enterococcus faecalis, both a commensal of the gastro-intestinal tract and a common nosocomial pathogen, ranges from 24% to 77% in post-treatment root canal infections. To date it has not been ...
Telomerase activation and its clinical implications in human thyroid tumors
(2015-09-22)
Telomerase is a ribonucleoprotein enzyme. The catalytic and rate-limiting component of telomerase is referred to as telomerase reverse transcriptase (TERT) that plays an important role in telomere maintenance, cell ...
Diabetes among Turkish immigrants in Sweden : a study of prevalence and risk factors
(2013-08-28)
Background: Risk factors associated with the difference in susceptibility to diabetes in different ethnic groups are poorly understood. This thesis investigates differences in prevalence of, as well as risk factors for, ...
Congenital adrenal hyperplasia : pre-and postnatal treatment effects on cognition, behavior and brain resting-state functional connectivity
(2022-04-14)
Congenital adrenal hyperplasia (CAH), an autosomal recessive disorder affecting adrenal steroid synthesis, is linked to impaired adrenal synthesis of cortisol and aldosterone. The increased production of androgen precursors ...
Vaccination in gastrointestinal cancer
(2014-01-31)
Advances in immunology have increased the possibility to develop therapeutic cancer vaccines (TCV), as a complementary approach to standard treatment. The goal of a successful cancer vaccine is to induce a potent long-lasting ...
Biased signalling at the IGF-1R : pitfalls and potential of the GRK/beta-arrestin system in cancer therapeutics
(2018-05-25)
Embedded into the boundary between the living machinery and the external space, plasma membrane receptors allow cells to perceive their environment and elicit appropriate responses. Two of the largest classes of receptors ...
Interplay between mitochondria, primary cilium, diabetes and its complications
(2016-12-12)
Diabetes is one of the major health problems of the 21st century. Dysfunction of the insulin secreting pancreatic β-cell together with insulin resistance is central to the pathogenesis of type 2 diabetes mellitus (T2DM). ...
Att vara fysiskt aktiv under adjuvant cytostatikabehandling : interventionsstudier för personer med bröst- och kolorektalcancer
(2017-01-12)
Bakgrund: Regelbunden fysisk aktivitet har sedan länge visat sig vara viktigt för att upprätthålla en god hälsa hos människor och det är känt att fysisk inaktivitet är en betydande riskfaktor för en rad olika hälsoproblem ...