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Matrix degrading proteases in vascular disease
(2002-11-22)
Diverse processes of vascular disease including lesion growth, plaque rupture and abdominal aortic aneurysm formation are influenced by protease expression. Arteries undergo compensatory remodelling when the mechanical ...
Kynurenic acid in psychiatric disorders : studies on the mechanisms of action
(2010-04-02)
Kynurenic acid, a metabolite of tryptophan along the kynurenine pathway, is an endogenous antagonist at NMDA- and α7* nicotinic acetylcholine- (α7*nACh) receptors. Previous studies have shown that elevated levels of ...
Endogenous kynurenic acid and schizophrenia : physiological and pharmacological aspects
(2006-05-12)
Kynurenic acid is a glutamate receptor antagonist with a preferential action at the glycine/Dserine site of the N-methyl-D-aspartic acid (NMDA) receptor. The compound is a metabolite of tryptophan and is synthesized in ...
Diet and gastrointestinal cancer : one-carbon metabolism and other aspects
(2006-11-23)
Diet has been hypothesized to play a major role in the etiology of gastrointestinal cancer, but the specific dietary factors involved remain unclear. The aims of this thesis were: to examine the associations of dietary ...