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Diet and gastrointestinal cancer : one-carbon metabolism and other aspects
(2006-11-23)
Diet has been hypothesized to play a major role in the etiology of gastrointestinal cancer, but the specific dietary factors involved remain unclear. The aims of this thesis were: to examine the associations of dietary ...
Expression of prostaglandin E synthase-1 in periodontitis : in vivo and in vitro studies
(2014-05-07)
Periodontitis is a chronic inflammatory disease characterized by destruction of the supporting structures of the teeth, including gingival tissues and alveolar bone. In advanced cases of periodontitis the ultimate clinical ...
Persistent inflammatory pathways in rheumatoid arthritis despite anti-rheumatic treatment
(2010-11-18)
The past years have witnessed tremendous progress in the treatment of rheumatoid arthritis, a chronic debilitating autoimmune disease mainly characterized by joint inflammation with progressive tissue destruction and loss ...
Prostaglandin E synthases in periodontitis-affected gingival tissue and in gingival fibroblasts
(2011-05-18)
Periodontitis is a chronic inflammatory disease resulting in the destruction of the tissue and alveolar bone supporting the teeth and leading ultimately to tooth loss. Prostaglandin E2 (PGE2) is an important inflammatory ...
mPGES-1 : a key regulator of fever and neonatal respiratory depression
(2006-05-24)
Prostaglandins are potent lipid mediators, synthesized de novo from arachidonic acid (AA) upon cell activation. AA is oxidized by the cyclooxygenase isoenzymes (COX-1 and COX-2) to form PGH2, the common substrate for ...
Inhibition of mPGES-1 as therapeutic strategy in inflammation and cancer
(2019-05-16)
Prostaglandin E2 (PGE2) is an inflammatory and oncogenic lipid mediator. It is mainly formed via metabolism of arachidonic acid by cyclooxygenases (COX-1 and COX-2) and the terminal enzyme microsomal prostaglandin E ...
Structure and function of microsomal prostaglandin E synthase-1
(2010-11-22)
The glutathione-dependent enzyme microsomal prostaglandin E synthase-1 (MPGES1) plays a pivotal role in inflammatory diseases. MPGES1 is up-regulated by pro-inflammatory cytokines in concert with cyclooxygenase (COX) -2, ...