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Role of toll-like receptors in host responses to mucosal bacterial infections
(2002-11-15)
The first contact between invading bacteria and the host occurs at the mucosal surface. Interestingly, the mucosal linings of different organs are exposed to bacteria to various degrees. The intestinal epithelium is ...
Treatment of uncomplicated malaria in Guinea-Bissau
(2006-03-10)
Treatment of malaria has become increasingly difficult due to high levels of resistance to the cheap and commonly used antimalarials. In Guinea-Bissau, the first line drug is chloroquine (CQ), the second line drug is ...
Human 15-lipoxygenase-1 and telomerase gene expression in cancer and inflammation
(2008-03-07)
Human 15-lipoxygenase type 1 (15-LOX-1) is an enzyme that catalyzes the oxygenation of free or membrane-bond polyunsaturated fatty acids containing at least one bis-allylic methylene moiety. The enzyme has been proposed ...
Studies of histone modification systems in Schizosaccharomyces pombe
(2010-05-26)
The genetic information in every cell is carried in the DNA. In eukaryotes the DNA is wrapped twice around proteins called histones forming a repeating unit called the nucleosome, in fibers known as chromatin. Nucleosomes ...
Post-translational modification of estrogen receptor alpha and p53 in breast cancer cells
(2015-08-21)
Estrogen receptor α (ERα/ESR1) and tumor protein p53 (p53/TP53) signaling are aberrant and play important roles in breast cancer pathogenesis and evolution. ERα is highly expressed in the majority of breast cancers and is ...
Detecting novel effects of exercise or AMPK activation in human skeletal muscle
(2018-04-24)
Cardiovascular and metabolic disorders are among the main causes of death today. Regular exercise can prevent and treat these chronic diseases. A molecule at the center of exercise adaptations in skeletal muscle is adenosine ...
Non-urgent and heavy use of the emergency department : intervention and follow-up studies
(1989-08-18)
The "inappropriate" use of emergency departments (EDs) - for non urgent or minor ailments and high-frequency use, "heavy use" - is causing great concern to several Western countries, irrespective of differing health care ...
Breast reconstruction with biological graft : clinical outcomes in the setting of breast cancer treatment
(2021-11-25)
The overall aim of this thesis was to investigate the use of acellular dermal matrix (ADM) in implant-based breast reconstructions (IBBR) in the setting of breast cancer treatment. ADM refers to a surgical mesh developed ...
Studies of side effects related to adjuvant breast cancer regimens with focus on chemotherapy
(2020-03-26)
Radiotherapy, endocrine therapy, chemotherapy and targeted therapy adjunct to surgery have a critical role in the management of early breast cancer for outcome improvement. Anthracycline containing chemotherapy reduces ...