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The human antimicrobial peptide hCAP18 in epithelial defense
(2001-11-16)
Gene-encoded antimicrobial peptides serve a protective role in host defense. They are multifunctional effector molecules in innate immunity - the nonadaptive immune system -with the capacity to kill a broad spectrum of ...
Plasma cell malignancies in Sweden : subgroup descriptions and regional outcomes for multiple myeloma
(2022-04-13)
Plasma cell disorders appear in various forms such as aggressive plasma cell leukemia (PCL), typical symptomatic multiple myeloma (MM), non-symptomatic smouldering multiple myeloma (SMM) and solitary plasmacytoma (SP). The ...
Severe psychological stress associated with a cancer diagnosis
(2018-10-04)
Receiving a cancer diagnosis leads to severe psychological distress. Previous studies have shown increased risk for various health consequences following a cancer diagnosis, including mental disorders, life-threatening ...
The functional organization of nuclear envelope proteins
(2014-09-05)
In eukaryotic cells, the nucleus is enclosed by a double lipid membrane, termed the nuclear envelope (NE). The NE consists of the outer nuclear membrane (ONM), the inner nuclear membrane (INM), the nuclear pore complexes ...
Dynamic protein trafficking of the nuclear membrane and peroxisomes
(2009-01-30)
The cell nucleus is enclosed by the nuclear envelope (NE), a double lipid membrane separating the nucleoplasm from the cytoplasm. Transport of macromolecules between the nucleus and the cytoplasm takes places through nuclear ...
The diverse role of laminin isoforms in neuronal cells, human mast cells and blood platelets
(2007-02-02)
The close interaction of cells with other cells and with extracellular
matrix (ECM) components is a prerequisite in a number of biological
activities. During development of the nervous system, axons often
navigate a ...
Vascular remodeling in pulmonary hypertension
(2015-05-22)
Pulmonary hypertension (PH) is a progressive obliterative vasculopathy with multifactorial etiology and high mortality rate. Endothelial dysfunction, excessive vascular remodeling, inflammation and in situ thrombosis ...
HMGB1 in inflammation : secretion and function
(2008-11-07)
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised
by progressive joint destruction. The inflammatory and joint destructive
processes in RA are mediated by resident synovial cells and cells
recruited ...
Role of c-Myc in the regulation of rDNA transcription by RNA polymerase I
(2010-04-30)
Ribosomal biogenesis and protein translation are finely coordinated with cell proliferation. All three RNA polymerases Pol I, II, and III are utilized for highly efficient and accurate ribosome production. The transcriptional ...
The role of Notch signaling in cancer and metastasis
(2014-01-24)
The Notch signaling pathway is an evolutionary conserved cell-to-cell communication pathway that regulates many important aspects in the development and tissue homeostasis of multicellular animals. It operates in a wide ...