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The functional organization of nuclear envelope proteins
(2014-09-05)
In eukaryotic cells, the nucleus is enclosed by a double lipid membrane, termed the nuclear envelope (NE). The NE consists of the outer nuclear membrane (ONM), the inner nuclear membrane (INM), the nuclear pore complexes ...
Prevalence and impact of chronic diseases and multimorbidity in the aging population : a clinical and epidemiological approach
(2008-02-19)
Due to the aging of the population, the absolute number of subjects
affected by age-related diseases is expected to increase as well as their
coexistence known as multimorbidity.The aims of this thesis were to
evaluate ...
Acute and early chronic responses to resistance exercise using flywheel or weights
(2008-05-15)
Weight training typically offers constant external load during coupled shortening (concentric) and lengthening (eccentric) muscle actions in sets of consecutive repetitions until failure. However, skeletal muscle inherently ...
Orofacial aspects of juvenile idiopathic arthritis in children
(2023-04-04)
Aims: This thesis, which investigates orofacial aspects and temporomandibular joint (TMJ) involvement in juvenile idiopathic arthritis (JIA), aims to improve knowledge about the variables to include in a clinical examination, ...
Prostate cancer diagnostics : complications and ways to reduce unnecessary biopsies
(2014-12-29)
Introduction: Prostate cancer is the most common form of cancer among men in Sweden.
There has been a rapid increase in the incidence rate of prostate cancer following the
introduction of PSA testing and, today, more ...
Surgical reconstruction of functional and anatomical defects in the diaphragmatic hiatus
(2022-05-10)
Gastroesophageal reflux disease (GERD) is characterized mainly by heartburn and acid regurgitation but in the more severe forms even organic manifestations can occur. Proton pump inhibitors (PPIs) is the main medical ...
Penumbra oxygen metabolism and acute neuroinflammation in ischemic stroke : MRI and PET imaging of a M2 occlusion model in rat
(2020-03-04)
Acute ischemic stroke (AIS) is caused by the sudden occlusion of a major artery of the brain, and results in infarction and severe ischemia within affected brain regions. If ischemic regions are rapidly revascularized, the ...
Standardizing diagnostic assessment of autism spectrum disorder : assets and challenges
(2015-11-27)
The overall aim of this thesis was to study some previously under-researched psychometric properties of the standardized diagnostic instruments Autism Diagnostic Interview-Revised [ADI-R] and Autism Diagnostic Observation ...
Diagnostic and predictive factors in pancreatic cancer : clinical and translational studies
(2022-09-28)
Aims: The aim of Study I was to assess the effectiveness of chemotherapy for patients with advanced pancreatic cancer in a real-world setting. Study II aimed to evaluate the utility of a clinical decision support system ...