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Reproductive aspects of the protein C system in women
(2001-03-09)
Of great importance to the reproductive system in women are the activating and inhibiting factors which maintain haemostatic balance. These play a prominent role in the prevention of abnormal bleeding, at ovulation as well ...
Studies on the hormonal regulation of bile acid synthesis
(2007-01-05)
The maintenance of a normal turnover of cholesterol is of vital
importance, and disturbances of cholesterol metabolism may result in
several important disease conditions. The major route for the elimination
of cholesterol ...
Redox-regulation of PTPs : mechanisms and impact on PDGFR signaling
(2013-05-23)
Protein tyrosine phosphatases (PTPs) are reversibly oxidized upon activation of platelet-derived growth factor receptor beta (PDGFβR). Dys-regulation of the PDGFβR signaling pathway is associated with several diseases, ...
Venous thrombosis in children : the roles of vascular access and critical illness
(2022-11-18)
Venous thromboembolism (VT) is a rare event in the general pediatric population. However, the incidence in hospitalized children is higher and has increased dramatically reaching 58 per 10 000 children. The single most ...
Novel combination chemotherapy for treatment and control of schistosomiasis among school children
(2021-05-21)
Despite reported success in reducing severe disease-associated morbidities in endemic countries, praziquantel (PZQ) alone has failed to control and eliminate schistosomiasis, partly due to its poor efficacy against ...
Oxidative stress and muscle weakness associated with rheumatoid arthritis
(2020-01-31)
Muscle weakness is a common comorbidity of several severe diseases which results in a reduced independence and quality of life and for the afflicted patients. For instance, patients with rheumatoid arthritis (RA), a disease ...
Thioredoxin and glutaredoxin systems under oxidative and nitrosative stress
(2017-03-16)
Our knowledge about reactive oxygen species (ROS) and reactive nitrogen species (RNS) has been changed from simple damaging molecules to redox signaling mediators. ROS/RNS mediated signaling is mainly based on the reversible ...