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Oxidative stress and muscle weakness associated with rheumatoid arthritis
(2020-01-31)
Muscle weakness is a common comorbidity of several severe diseases which results in a reduced independence and quality of life and for the afflicted patients. For instance, patients with rheumatoid arthritis (RA), a disease ...
Neonatal respiratory control : inspiration, inflammation and the prostaglandin E2 pathway
(2014-10-22)
Immature or deficient autonomic control is a common problem in infants born at a premature age, and is of central importance in apneas. The pre- and perinatal development of the brainstem neural circuits that control ...
HCMV-induced epigenetic alterations : a novel pathway to CNS tumors?
(2018-06-01)
Aberrant DNA hypermethylation at CpG islands is a well-established phenomenon involved in transcriptional silencing of tumor suppressor genes. CpG island hypomethylation-mediated reactivation of oncogenes is also documented ...
From health outcomes to value assessments : preference-based evaluation of interventions and valuation of productivity costs among working adults
(2017-08-28)
Background: This thesis applies value assessment frameworks to non-specific low back pain (LBP) in a working population to evaluate health outcomes and to estimate productivity costs. LBP is a common diagnosis in primary ...
Myeloid cells in autoimmune diseases
(2014-03-21)
Multiple Sclerosis (MS) and Type 1 Diabetes (T1D) are autoimmune diseases caused by dysregulation of the immune system. Monocytes/macrophages are myeloid cells that play a pivotal role in both induction and resolution of ...