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Studies of the recognition and activation of natural killer cells
(2000-11-23)
Natural killer (NK) cells mediate part of the innate immune response that impedes the spread of invading microorganisms and shapes the downstream adaptive immune response. NK cells spontaneously kill tumor cells and other ...
VEGF-B in islet of langerhans : role in vascular signaling and lipid handling
(2020-02-13)
The discovery of Vascular endothelial growth factor (VEGF)-B’s role in endothelial fatty acid uptake and tissue lipid accumulation opened a new arena for exploration of VEGF-B in lipid metabolism. Indeed, later studies ...
Transcriptional and post-transcriptional regulation of telomerase reverse transcriptase (hTERT) expression : the role of histone modification and alternative splicing
(2008-01-18)
Telomerase, an RNA-dependent DNA polymerase responsible for telomeric DNA
elongation, is silent in most normal differentiated human cells due to
the tight repression of its catalytic unit, telomerase reverse
transcriptase ...
Microsomal prostaglandin E synthase 1 and microsomal glutathione transferase 1 : inhibition and mechanism
(2014-05-16)
The Membrane-Associated Proteins in Eicosanoid and Glutathione Metabolism (MAPEG) is
a family of six membrane bound proteins with different biological functions. MAPEG
superfamily members enable and catalyze reactions ...
Regulatory function of homeobox genes in the development of C. elegans
(2010-09-10)
The nematode worm Caenorhabditis elegans has been widely used as a genetic model for over 40 years to investigate developmental control genes. In this thesis, I studied the roles of several homeobox genes and a novel RNA ...
In vivo functions of mammalian glutaredoxin 2
(2008-08-29)
Oxygen is essential for all respirating life forms. However, the use of molecular oxygen as terminal electron acceptor of the respiratory electron chain leads to the generation of reactive oxygen species (ROS) as product ...
Chemokines and chemokine receptors during viral infections in man
(2007-11-08)
Chemokines and chemokine receptors are critical mediators of cell migration during immune surveillance, inflammation and development. The generation of antibody responses depends on B and T cell collaboration within germinal ...
Protein expression analysis of insulin producing cells exposed to endoplasmic reticulum stress
(2015-01-30)
The prevalence of type 2 diabetes mellitus (T2DM) is increasing rapidly as a result of the obesity epidemic. T2DM develops in individuals who fails to compensate for increased demand of insulin. Obese individuals display ...
Regeneration of the auditory nerve : a cell transplantation study
(2011-11-28)
Since in mammals, the hair cells or the spiral ganglion neurons (SGNs) in the inner ear do not regenerate, damage to these cells is an irreversible process. Presently the only aid for patients with severe to profound hearing ...
Mitochondria : a target for anticancer therapy
(2014-12-17)
Mitochondria possess a central role in several cellular metabolic pathways, maintenance of calcium homeostasis, production of reactive oxygen species (ROS) and in the regulation of various cell death modalities. A majority ...