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Transcriptional and post-transcriptional regulation of telomerase reverse transcriptase (hTERT) expression : the role of histone modification and alternative splicing
(2008-01-18)
Telomerase, an RNA-dependent DNA polymerase responsible for telomeric DNA
elongation, is silent in most normal differentiated human cells due to
the tight repression of its catalytic unit, telomerase reverse
transcriptase ...
Mitochondrial dysfunction in ageing and degenerative disease
(2007-10-05)
The cytoplasm of eukaryotic cells contains a dynamic network of
double-membraned organelles, called mitochondria, which perform the
process of oxidative phosphorylation (OXPHOS) that provides cellular
energy in the form ...
Nucleoside analog toxicity and nucleoside kinase deficiency : effects on mitochondrial DNA
(2008-09-05)
Nucleoside analogs are modified nucleosides used in treatment of cancer
and viral infections. They are dependent on intracellular phosphorylation
to be pharmacologically active. Deoxyribonucleoside kinases catalyze ...
Generation and transmission of mtDNA mutations and their effect on aging
(2013-12-20)
Mutations in mtDNA are known to cause neuromuscular diseases and have been associated with several common age-associated diseases as well as being a contributor to the aging process. Despite their importance there are still ...
Mitochondrial DNA mutations : brain developmental and ageing consequences, and possible treatments
(2012-09-06)
Ageing is a complex process that involves cellular senescence, a gradual loss of tissue homeostasis, and decline in organ function. Abundant evidence implicates mitochondria in ageing suggesting: (i) accumulation of ...