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Microsomal prostaglandin E synthase 1 and microsomal glutathione transferase 1 : inhibition and mechanism
(2014-05-16)
The Membrane-Associated Proteins in Eicosanoid and Glutathione Metabolism (MAPEG) is
a family of six membrane bound proteins with different biological functions. MAPEG
superfamily members enable and catalyze reactions ...
Evaluation of a metal-on-metal total hip arthroplasty
(2017-01-17)
Background: After the introduction of the Metasul system by Weber in 1988, total hip arthroplasty (THA) with metal-on-metal (MoM) bearings became increasingly popular in the 1990s. MoM bearings aimed to reduce the problem ...
Cardiovascular comorbidity in rheumatoid arthritis
(2010-10-29)
This thesis is based on four different studies, all focusing on co-morbidities in rheumatoid arthritis. Diabetes mellitus is assessed as a risk factor for rheumatoid arthritis, the temporal relationship between ischemic ...
Health effects of snus use : cardiovascular diseases, weight gain and obesity
(2012-11-08)
Use of snus is most prevalent in Nordic countries, and especially in Sweden, where 18% of men and 3% of women are daily users. Snus is also used to a minor extent in the United States where an increasing interest is seen ...
HCMV-induced epigenetic alterations : a novel pathway to CNS tumors?
(2018-06-01)
Aberrant DNA hypermethylation at CpG islands is a well-established phenomenon involved in transcriptional silencing of tumor suppressor genes. CpG island hypomethylation-mediated reactivation of oncogenes is also documented ...
Health-related quality of life after oesophageal cancer surgery for prediction of morbidity and mortality
(2010-10-01)
This thesis investigates the health-related quality of life (HRQL) among surgically treated oesophageal cancer patients. The established curative treatment for oesophageal cancer is extensive surgery with a high risk of ...
New potential targets in medulloblastoma therapy : studies on cellular mechanisms and mediators
(2010-01-15)
Medulloblastoma is an embryonal tumour that mainly affects children. It
is the most common malignant brain tumour in children and accounts for
15% of all childhood brain tumours. It most often presents in the
cerebellum ...