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Repression of transcription factor NF-[kappa]B by glucocorticoids : a molecular mechanism for their anti-inflammatory and immuno-modulatory effects
(2000-11-21)
It has been known since the late 1940s that glucocorticoids (GCs) possess anti-inflammatory activity. Their various uses in the clinic include treatment of, rheumatoid arthritis, asthma and AIM skin diseases and also as ...
Genetic and immunological studies of experimental arthritis, with emphasis on a novel C-type lectin receptor gene complex
(2009-03-05)
Rheumatoid Arthritis (RA) is a chronic, systemic autoimmune syndrome primarily affecting peripheral joints. The etiology of RA is largely unknown but complex interactions between genetic and environmental factors contribute ...
Pulmonary manifestations in smoking-related diseases : clinical studies with emphasis on chronic obstructive pulmonary disease and rheumatoid arthritis
(2014-10-03)
Smoking is a risk factor for a number of diseases including chronic obstructive
pulmonary disease (COPD) and rheumatoid arthritis (RA). Cigarette smoke initiates
an inflammatory response which leads to structural changes ...
Epidemiological studies in Malaysia and Sweden on associations between smoking, silica exposure and the risk of developing rheumatoid arthritis
(2012-11-12)
Rheumatoid arthritis (RA) is a chronic, inflammatory disease, frequently associated with joint destruction. Knowledge regarding the aetiology of RA is mainly generated on Caucasian populations. Less is known about RA in ...
Hairdressers : hand eczema, hair dyes and hand protection
(2006-10-06)
Hand eczema is a well-known problem in occupations that involve largely manual work, in combination with long periods of wet exposure and skin contact with chemicals. Hairdressing involves dermal exposure to a number of ...
Actin and myosin in transcription and chromatin regulation
(2016-05-02)
In mammalian cells, actin and myosin have emerged as regulators of nuclear structure and function, involved in chromatin remodeling and histone modifications, and in different phases of gene transcription. Actin and myosin ...
Neuropeptides and spinal antinociception : studies on galanin, nociceptin and endomorphin
(2003-05-29)
Nociception and/or the sensation of pain is essential for the survival of the organism. Just as important are the antinociceptive mechanisms that reduce the nociceptive input and perceived pain. Without such mechanisms, ...
Mitochondria and cellular energy metabolism in platinum chemotherapy
(2009-09-18)
Chemotherapy is a major strategy in the treatment of cancer. Unfortunately, treatment of advanced cancers often fails due to tumor resistance to chemotherapeutic drugs. Studies of cell death signaling induced by chemotherapeutic ...
Novel treatment of African trypanosomiasis
(2013-01-25)
Human African Trypanosomiasis (HAT) or Sleeping Sickness is fatal if untreated. Current drugs used for the treatment of HAT have difficult treatment regimens and unacceptable toxicity related issues. The effective drugs ...
Insights into the role of spinal mTOR in the modulation of inflammation and nociception
(2012-05-04)
Pain, especially chronic pain, is a major clinical problem. Pain therapy has proven to be complicated and the results are often unsatisfactory. Despite many years of research, the number of available pain therapeutics ...