Search
Now showing items 1-4 of 4
Biased signalling at the IGF-1R : pitfalls and potential of the GRK/beta-arrestin system in cancer therapeutics
(2018-05-25)
Embedded into the boundary between the living machinery and the external space, plasma membrane receptors allow cells to perceive their environment and elicit appropriate responses. Two of the largest classes of receptors ...
Nitric oxide formation from inorganic nitrate and nitrate : contribution from eukaryotic and prokaryotic pathways
(2011-10-19)
Nitric oxide (NO) is an essential signaling molecule that plays a central role in a broad range of physiological functions. Classically, NO is synthesized from L-arginine and molecular oxygen by NO synthases. Once formed, ...
Inorganic and organic nitrates as sources of nitric oxide
(2012-05-15)
Inorganic nitrate (NO3-) and nitrite (NO2-) have generally been considered stable inactive end products of nitric oxide (NO) or unwanted residues in the food chain. While several recent studies surprisingly demonstrate ...
The role and regulation of nitric oxide and oxidative stress in cardiometabolic disease : focus on preeclampsia
(2022-04-29)
Cardiovascular (CVD) and metabolic diseases account for significant morbidity and mortality. Over the last decades, despite significant research and clinical effort, their global prevalence is estimated to further increase. ...