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Illuminating tissue organization by imaging the spatial transcriptome
(2022-12-19)
Our bodies consist of a large collection of cells that each have their own function in the organ that they reside in. The cells are grouped by functionality in cell types that arise during development as the result of the ...
Plurifaceted proteomics in studying cellular dynamics and action mechanisms of anticancer drugs
(2021-05-05)
Mass spectrometry (MS)-based proteomics has developed tremendously in recent years and was the leading technology for many novel methods to study protein chemistry. Contrary to classical approaches based on Western blot, ...
Transcriptomic cellular diversity of the early human developing brain
(2023-01-27)
The complexity of the mammalian brain is partly reflected in its cell type diversity which influences the function of neurons that encode the behavior of animals. Brain cell type diversity emerges during embryonic stages, ...
Clonal structures and cell interactions in cancer
(2023-05-29)
Despite sharing an identical genome, cells of higher order multicellular organisms display a large
degree of phenotypic diversity. This diversity is maintained by a sophisticated regulatory machinery
that integrates ...
3D imaging and quantitative analysis of intact tissues and organs
(2020-04-17)
Embryonic development and tumor growth are highly complex and dynamic processes that exist in both time and space. To fully understand the molecular mechanisms that control these processes, it is crucial to study RNA ...
Brain development in a dish
(2020-03-06)
This thesis shows the path I took in the quest for modeling the brain, as the title says, in a dish. The introduction of induced pluripotent stem cells (iPSCs) as means to research biological processes has opened up whole ...
Diabetes among Turkish immigrants in Sweden : a study of prevalence and risk factors
(2013-08-28)
Background: Risk factors associated with the difference in susceptibility to diabetes in different ethnic groups are poorly understood. This thesis investigates differences in prevalence of, as well as risk factors for, ...
Long non-coding RNAs and cellular interactions : investigating underlying mechanisms of oncogenesis
(2019-11-06)
Cancer is a leading cause of death worldwide with one in 8 men and one in 11 women dying from the disease (World Health Organization, 2018). Despite vast improvements in cancer diagnosis and therapy, the global cancer ...
Integrative omics data analysis to discover novel signatures in complex diseases
(2023-03-09)
Apart from diseases caused by the defect of a single gene, most diseases are highly complex and are usually caused by a combination of biological and environmental factors. In the biological context, cellular processes are ...
Methods development for the investigation of the mammalian genome radial architecture : the quantitative side
(2021-04-16)
The nucleus of mammalian cells cradles the genome, an ensemble of nucleic acid macromolecular polymers that store information in a physical form. For a cell to perform life-sustaining processes, reading and utilizing the ...